Postdoctoral Researcher in Gene Regulation

We are seeking a highly motivated, ambitious and enthusiastic Postdoctoral Researcher to research programs addressing alpha globin gene regulation and nuclear organization.

The overall aim of this research program is to understand the principles by which mammalian genes are regulated throughout development and differentiation. In particular we will use both the human and mouse alpha globin clusters to address these key questions in current biology. To complement the work, we do in human systems, we engineer mutations in the mouse locus that correspond to human variants and study the molecular mechanisms driving the observed human phenotypes. In addition, we engineer fully characterised mouse cell lines to address the current unsolved issues underlying gene regulation.

You will hold a PhD/DPhil, or be close to completion (thesis submitted at the time of application) in a relevant subject.  Experience in genome editing and genome engineering at various scales and in rapid protein depletion systems such as the dTAG system are essential.  Furthermore, you will have experience in immunophenotyping (staining and analysis by FACS) and purification of desired populations based on different approaches (magnetic column purification and cell sorting).

Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings is essential.

The post is fixed-term until 31 March 2025, funded by the Medical Research Council.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12 noon on 22 January 2024.