We are seeking to appoint a Postdoctoral Research Scientist in Structural Vaccinology to carry out a structural and functional investigation of the rabies virus glycoprotein (RVG) within the Jenner Institute located at the Wellcome Centre for Human Genetics. This is an exciting opportunity to join the Institute's world-leading vaccine development team and contribute to the structural and functional characterisation of the RVG to enable the design of novel rabies vaccines.
You will participate in the structural and functional studies of the RVG. This will involve producing and purifying recombinant RVG as well as various RVG-specific antibodies and proposed cellular binding partners, conducting protein-protein interaction studies and cryo-EM characterisation of the protein complexes. Rabies is a 100% fatal disease that kills around 59, 000 people per year. Your work will enhance our understanding of virus entry and elicit vulnerabilities that can be exploited for the development of the next generation of novel and more efficient rabies vaccines.
You will have to manage your academic research and administrative techniques and present results clearly, interpret them, and communicate them to other members of the team, while doing small scale project management. You will also take part in the structural and functional studies of the optimised rabies antigen. This will include analysing scientific data from a variety of sources, testing, reviewing and refining working hypotheses; experimental design, execution, analysis, and reporting; adapting existing and developing new scientific techniques and protocols.
You will be educated to a PhD/DPhil degree (or close to completion) in a relevant Biological Sciences or related subject. Experience in protein expression and purification, and single-particle cryo-EM is essential. You will have excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings.
Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Additional security pre-employment checks will need to take place for all successful applicants. This includes a satisfactory enhanced Disclosure check and a University Enhanced Level Screening.
This position is fixed-term contract until 23 March 2022 in the first instance and funding is provided by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID).
Please quote 146667 on all correspondence.
Only applications received before 12.00 noon on 4 August 2020 will be considered. Interviews will be held on Wednesday 12 August 2020.
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