We are seeking a highly motivated and talented Computational Biologist with experience in Next Generation Sequencing data analysis and machine-learning and/or statistical modelling to join our group to study the underlying rules of T cell receptor interaction with MHC presented peptides by leveraging multimodal single cell data from various cutting-edge technologies. Familiarity with TCR/BCR or antigen data is desirable but not essential for this post.
The research in our group is focused on the use of systems/quantitative immunology to foster a better understanding of the mechanisms underpinning the regulation of adaptive immune system in healthy individuals. The aim of these studies is to pave the way to further our knowledge of functional and molecular mechanisms linked to dysregulation of the immune system in serious human health challenges such as cancers, infectious/autoimmune diseases and aging.
Over the past couple of decades owing to the cutting-edge advances in high throughput sequencing and single cell profiling technologies, the field of life science –especially immunology– has faced the challenge of unprecedented amount of very complex, multi-dimensional data. Understanding such data and extracting the sound biological knowledge has become more complicated than performing the experiments. As such, quantitative approaches including statistical inference and machine-learning techniques especially the cutting-edge deep neural networks have proven very successful.
In this regard, the current research theme in our group is specifically focused on T cells response and function in which multi-modal high throughput sequencing ‘big data’ from the cutting-edge bulk and single cell technologies are incorporated into computational, machine-learning and statistical models to study T cell recognition of self and foreign pathogens. This post is to focus on developing machine-learning and statistical models to further advance our understanding of the rules underpinning T cell receptor recognition of its cognate peptides using single TCR and transcriptomics data. The work will involve collaboration with computational biologists in the group as well as with other immunologists in HIU undertaking antigen-specific (Prof. Simmons’ lab) and/or lipid-specific (Prof. Ogg’s lab) T cell experiments employing cutting edge single cell technologies.
You will hold a PhD/Dphil of relevance to systems and quantitative immunology experience of research within bioinformatics. A strong background in machine-learning/or and statistical inference and/or data science is essential. You will possess the ability to independently plan and manage a research project. A background or knowledge in T and B cell Immunology and experience of computational biology of immune repertoire data (TCRs and BCRs) is desirable.
The post is full-time and fixed-term for up to 2 years, with a possibility of extension. Flexible working can be discussed during the interview process.
Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application.
Only applications received before 12:00 midday on Friday 12 November 2021 will be considered.
Similar Positions
-
Postdoctoral Research Assistant In Engineering Biology , ;, United Kingdom, 22 days ago
We are seeking a full-time PDRA to join Oxford Centre for Tissue Engineering and Bioprocessing (OCTEB) at the Institute of Biomedical Engineering, Department of Engineering Science (Headington). T...
-
Postdoctoral Researcher In Cellular Therapeutics , ; University of Oxford, United Kingdom, about 17 hours ago
Contract type: Fixed-term contract until 30th June 2026 About the role We are looking for a postdoctoral researcher to work in Translational Research Immunology Group (TRIG) on translational, coll...
-
Post Doctoral Scientist, Oxford Mnd Centre , ;, United Kingdom, 22 days ago
We are looking for an enthusiastic postdoctoral researcher looking to develop an independent research career is required for a cutting-edge program of research to systematically investigate calciu...
-
Postdoctoral Research Associate In Genome Stability And Immunity Responses , ;, United Kingdom, 15 days ago
A postdoctoral position is available in Dr Ivan Ahel’s group at the Sir William Dunn School of Pathology, University of Oxford to study the interplay of ADP-ribosylation and ubiquitylation signall...
-
Post Doctoral Research Assistant Neuronal Biologist: “Biomarkers Of Lysosomal Dysfunction In Parkinson’s Disease” , ;, United Kingdom, 19 days ago
Applications are invited for a post-doctoral neuronal biologist to work on biomarker profiles of lysosomal dysfunction in pre-clinical models of Parkinson’s. The project, funded by the Michael J F...
-
Postodctoral Research Assistant In Bioengineering , ;, United Kingdom, 22 days ago
We are seeking a full-time PDRA to join Oxford Centre for Tissue Engineering and Bioprocessing (OCTEB) at the Institute of Biomedical Engineering of Department of Engineering Science (Headington)....