Postdoctoral Research Associate

This research is to understand heme peroxidase enzyme mechanism. For this we need to trap intermediates and determine the structures. There is controversy over the nature of these intermediates and we have used tools such as neutron crystallography and X-ray free electron lasers in the past which have resulted in high impact publications. Specific aims of this project include the direct determination of the protonation state of the Compound II intermediate of cytochrome c peroxidase using neutron crystallography and of the myoglobin analogue using neutron and XFEL techniques. We are also developing techniques for using micro crystal electron diffraction to study enzyme intermediates. We are interested in using a wide variety of biochemical and biophysical techniques to complement and verify the studies. This includes UV-Visible and X-ray spectroscopy.   The group (https://le.ac.uk/liscb/research-groups/peter-moody ) is based in the Leicester Institute for Structural and Chemical Biology (https://le.ac.uk/liscb ), a supportive and collegiate environment with access to world-class facilities and expertise.

This post is suitable for someone interested in expanding their experience of, and pushing the boundaries of, methods to understand enzyme mechanism. You will be competent working with proteins in the laboratory and want to learn about, and apply, physical and chemical techniques to biological problems.

Informal enquiries are welcome and should be made to Professor Peter Moody [email protected]

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