This post is made available through a Cancer Research UK - Programme Foundation Award. Dr Michele Mishto (Dep. of Immunobiology & CIBCI) is lead investigator of a project entitled “Identification of tumour-specific spliced epitopes to target large cohorts of cancer patients by immunotherapy”. The project is funded by Cancer Research UK (programme Foundation Award) for 6 years, beginning in 2021.
The successful candidate will be expected to lead, under the supervision of Dr Mishto, a programme of research whose principal aims are:
(i) to isolate CD8+ T cell clones specific for HLA-I-restricted spliced neoepitopes carrying recurrent driver mutations in in melanoma and pancreatic adenocarcinoma;
(ii) isolate and clone their TCRs and use them to investigate the epitope generation in cancer cells;
(iii) use TCRs to test their efficacy in treating cancer in xenograft mouse models.
Detailed knowledge of applied cellular and molecular biology and immunobiology, biochemistry cloning and mouse model would be highly advantageous.
The successful candidate will have opportunities to interact with national and international collaborators with a broad expertise, which varies from computational biology to clinics. This post will be located in the Centre for Inflammation Biology and Cancer Immunology (CIBCI) in New Hunt's House on the Guy's Campus, King's College London.
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