27 Feb 2024
Job Information
- Organisation/Company
KINGS COLLEGE LONDON- Research Field
Physics- Researcher Profile
Recognised Researcher (R2)
Established Researcher (R3)- Country
United Kingdom- Application Deadline
24 Mar 2024 - 00:00 (UTC)- Type of Contract
Other- Job Status
Full-time- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Job description
We are seeking a postdoctoral research associate to work on an exciting 2.5-year project to enhance therapeutic options for patients with neuroendocrine tumours. The postdoc will carry out cellular and preclinical dosimetry using (and acquiring if so desired) data from radiochemical/biological studies to create, characterise, and test new molecular radionuclide therapies beyond beta particle-emitters both in vitro and in vivo in tumour and healthy cells and tissues. Approaches will be both as single therapies and in combination with chemotherapies. Radionuclide imaging studies alongside the above data will be used to inform dosimetry. This post will work closely with a postdoc with biological expertise already in place.
Improvement of cancer treatment remains a priority as 28% of UK deaths are still attributable to cancer. Neuroendocrine tumours (NETs), whilst rare, are the exemplar cancer type investigated here as they are hard to treat. External beam radiotherapy and molecular radionuclide therapy in the form of 177Lu-DOTATATE have enhanced survival for some NET patients, but the long-term outlook for most patients with advanced NETs remains poor.
This work will 1) directly influence future clinical trial design in neuroendocrine cancer patients undergoing injectable radioactive therapy as part of their treatment, 2) provide evidence to convert radionuclide therapy from palliative to curative options in cancer, and 3) provide key building blocks with which to create other effective radionuclide therapies as well as impactful combination therapies.
The work spans cellular and preclinical tumour and health organ dosimetry and can be easily carried out by somebody with Monte Carlo modelling skills and a good understanding of the basic radiation dosimetry principles. Optional experimental work spans molecular biology, in vitro cell studies and preclinical in vivo therapy and radionuclide SPECT and/or PET imaging studies, and radiobiology.
In this post, the successful candidate will work closely with Dr Terry, her team, and industrial collaborators at Perspective Therapeutics, as well as collaborate with other members of the Department of Imaging Chemistry and Biology and scientists and clinicians at external institutions and universities.
The team is committed to providing an inclusive and supportive environment for all. See https://www.radlab.uk/team and associated pages for more on who we are and what we do.
This post will be offered on a fixed-term contract until 17 September 2026.
This is a full-time post - 100% full time equivalent.
Key responsibilities
- Cellular dosimetry to determine whole cell and nuclear absorbed dose from a range of radionuclides and radiopharmaceuticals in a range of cells.
- Whole body and organ/tumour-specific dosimetry based on preclinical imaging studies and ex vivo biodistribution studies.
- Monte Carlo modeling of range of scenarios ranging from beta, alpha and Auger-electron emitters to determine radiopharmaceutical-specific requirements from a dosimetry/physics perspective for optimal therapeutic efficacy.
- Accurate and comprehensive record keeping and robust documentation of data acquisition.
- The job holder will regularly gather data, conduct detailed analyses and interpret standard data/information, reporting and presenting findings as appropriate. They will assist others to acquire or interpret research data, highlighting any issues.
- Participate at conferences (national, international and internal conferences), including presenting posters and oral presentations.
- Prepare manuscripts in collaboration with supervisors and other members of the Department.
- Design and undertake experiments independently as well as in collaboration with others.
- Supervise, train, and assist junior laboratory members.
- Collaborate with other members of the department, lending skills to support other’s research, where appropriate.
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
Essential criteria
Desirable criteria
Requirements
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- KINGS COLLEGE LONDON
- Country
- United Kingdom
- City
- London (Central)
- Geofield
Where to apply
- Website
https://www.timeshighereducation.com/unijobs/listing/366267/postdoctoral-resear…
Contact
- City
London (Central)
STATUS: EXPIRED
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