There is an exciting opportunity for a Postdoctoral Research Associate in Cell Biology/Biochemistry in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences based at the Botnar Research Centre, Oxford. The laboratory of Dr John Christianson is seeking an exceptional, enthusiastic and motivated scientist to work on a research project investigating protein degradation mechanisms in cancer. You will join an interdisciplinary team of experimental scientists working in the fields of cell biology and myeloma drug resistance as part of the newly formed Oxford Centre for Translational Myeloma Research.
In this role, you will be developing methodology for the biochemical and functional characterisation of ubiquitin ligase complexes in the endoplasmic reticulum (ER), working with both in vitro and cell culture systems. The research project will involve a wide range of basic and advanced molecular/cellular biology and biochemical techniques, including but not limited to; cell culture, genomic manipulation (e.g. CRISPR), mass spectrometry, IP-WB, FACS, protein purification, high-throughput screening, and radiolabelling. You will manage your own academic research and administrative activities, while contributing to the dissemination of research group findings by authorship of manuscripts, presentations at meetings, and the group’s website.
We are seeking an individual with a PhD/DPhil (or be near completion) in cell biology, molecular biology, biochemistry or related discipline. You will have previous laboratory experience, good communication skills, and an ability to work both independently and as part of a team. Previous and relevant experience in ubiquitin-proteasome biology, protein quality control or membrane protein biochemistry is also essential. Experience in cell-based assay development, small molecule screening, ER biology, ER-stress and the UPR, or background in haematological cancer biology, is advantageous.
This is a full-time fixed-term appointment for 3 years.
You will be required to upload a CV and supporting statement as part of your online application.
The closing date for this position is 12.00 noon on Friday 28 February 2020.
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