Postdoctoral Project Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

THE GROUP

We are seeking a highly motivated stem cell biologist to join Prof Dominique Bonnet’s laboratory. The lab works on the regulation of human normal haematopoietic stem cell biology and leukemia and the role of the extracellular factors providing by the niche.

Details of research projects currently being undertaken in HSCL lab can be seen at: http s://www.c rick.ac.uk/research/a-z-researchers/researchers-a-c/dominique-bonnet/

We seek a talented, productive and motivated postdoc with a desire to work in a congenial, dynamic and collaborative research team. The post holder will be part of the team of researchers working in the Haematopoietic Stem Cell laboratory under the direction of Prof Dominique Bonnet.

PROJECT SUMMARY

The group is interested in studying normal human Haematopoietic Stem Cells (HSCs) and Leukaemic Stem Cells (LSCs). The present project funded by an internal translational scheme, is to investigate the ability to expand umbilical cord blood stem cell using a RET agonist compund developed by Propf Neil McDonald’s group.

The successful candidate will join the HSC team lead by Prof D Bonnet at the Francis Crick Institute. You will work on investigating which cell types are responding to the stimulation, using multiparameter FACS analysis as well as scRNAseq. Functional validation using ex vivo long-term culture as well as xenotransplantation model will be used.

PERSON SPECIFICATION  

The post holder should embody and demonstrate our core Crick values: Bold, Open,  and Collegial, in addition to the following:

Essential:

• PhD on stem cell biology,
• Experience in vivo modeling, FACS analysis
• Experience in molecular biology
• Experience on haematopoietic field
• Proven track record of research (e.g: publication record)
• Strong written and oral communication skills

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 04.04.2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.