Postdoctoral Fellow - Novel Drug Domains in Cancer Pathways

Updated: about 2 months ago
Location: Cambridge, ENGLAND
Job Type: FullTime
Deadline: 02 Jun 2021

Contract Length: 3 years

The Opportunity:

The Garnett lab  is seeking a postdoctoral fellow to develop and utilise CRISPR saturation genome editing to identify novel druggable domains in specific cancer pathways.

CRISPR gene editing represents a key technology for identifying opportunities for targeted cancer therapies. An area that has had relatively little attention involves linking this data directly to protein structural data for drug discovery. This could enhance our ability to interpret and utilise the results and to predict novel druggable targets and mechanisms.

You will join the Translational Cancer Genomics team led by Dr. Mathew Garnett to develop saturation CRISPR genome-editing in cancer cells to identify novel targetable domains for precision cancer therapies. The lab has extensive expertise in cancer genomics, CRISPR screening and cancer therapeutics. The project is a close collaboration with Astex Pharmaceutical, who are world leaders in structural bioinformatics and structure-based design applications for drug discovery.

This is a unique opportunity to work at the interface of academia and industry on a multi-disciplinary cutting-edge project that uniquely combines expertise in structural biology (Astex) and CRISPR/cancer genomics (Sanger).

For a full details and criteria, please download the job description.

To find out more about joining the Garnett Lab as a Postdoctoral Fellow, please visit here

Essential Skills

Technical Skills:

  • PhD in cancer biology, cancer therapeutics, biotechnology, cell biology, or related discipline 
  • Experience using CRISPR-based methodologies in mammalian cells 
  • Experience performing cell culture in cancer cell lines 
  • Experience performing molecular cloning, lentiviral production, Western blotting, flow cytometry, and viability assays 

Behavioural and Competencies:

  • Ability to communicate ideas and results effectively to diverse stakeholders through discussion, talks, and publications. 
  • Effective and confident decision making skills. 
  • Strategic thinking skills and the ability to embrace change and seek creative solutions to challenges
  • Ability to constructively resolve differences and conflict. 
  • Promote a positive, safe and efficient working environment.
  • Ability to engage and involve team members. 
  • Uphold the highest ethical and scientific standards. 

Ideal Skills

  • Experience using CRISPR base-editing 
  • Experience performing cell based screens 
  • Knowledge of R or Python programming languages 
  • Knowledge of structural biology 

Other information

Please apply with your CV and a cover letter outlining your suitability for the role addressing the criteria set out above and in the job description.

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