Postdoctoral Fellow - JPIAMR

Updated: 4 months ago
Location: Cambridge, ENGLAND

Postdoctoral Fellow - Evolution of Antimicrobial Resistance in Pneumococci through deep sequencing

Salary: £31115 to £39004 per annum depending on experience.

We are looking to recruit a postdoctoral researcher to lead the analysis of a major new international project, funded through the Joint Programming Initiative on Antimicrobial Resistance. This post provides for the exciting new opportunity to employ deep genomic sequencing of a large pneumococcal sample collection to study the clinical impact of antibiotic exposure through generating a high-resolution view of pneumococcal evolution.

We are seeking to appoint a talented individual skilled in bioinformatic analysis of large genomic datasets and able to interpret the important evolutionary and epidemiological results. They will work collaboratively as part of a multi-disciplinary team and be responsible for designing studies, bioinformatic analysis, interpretation of results, and delivering manuscripts describing the outcomes. The successful candidate will have the opportunity to develop innovative analytical approaches for a range of bacterial pathogens as part of the broader group’s research programme.

The post will be within the Pathogen Genomics Group at the Wellcome Trust Sanger Institute. The Group has a world class record of pioneering the use of large-scale genomic data analysis to understand pathogen biology, epidemiology and evolution. The applicant would be part of team engaged in many exciting ongoing project areas studying pathogen characteristics such as person-to-person transmission, global spread, acquisition of antimicrobial resistance and severity of disease. Our studies are supported by genomic, clinical and epidemiological data for thousands of samples providing opportunities for well-powered analyses for a range of major bacterial pathogens.

The ideal applicant will have a PhD and significant experience in statistical genetics, microbial genomics, computational biology, or a related discipline, with demonstrated expertise in applying multiple statistical approaches to the analysis of large datasets to infer biological insights. They will join a lively group that combines the expertise of microbiologists, phylogeneticists, clinicians, mathematicians, bioinformaticians and software developers.

For any questions about the position, please contact Stephen Bentley (sdb@sanger.ac.uk)


Essential Skills
  • PhD and experience in statistical genetics, microbial genomics, computational biology, or a related discipline
  • Demonstrated expertise in the management and analysis of very large genomic data sets
  • Demonstrated expertise in at least one relevant programming language
  • Proven track record of publishing high quality papers in reviewed journals
  • Excellent communication skills, ability to interact across a multi-disciplinary team to develop and maintain good working relationships
  • Keen to learn and share scientific ideas
  • Attention to detail
  • Excellent problem solving

Ideal Skills
  • Experience of writing software for application of novel analysis methods to large-scale data sets
  • Excellent quantitative skills and statistical knowledge     
  • Experience of undertaking research work within large multidisciplinary teams

Other information

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award are encouraged to apply. This position is initially for a fixed term for 3 years.

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date: 25th July 2017


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