Post-doctoral neuronal cell biologist: Targeting the epigenetic regulator HDAC4 as a therapy for Parkinson’s disease

Updated: 24 days ago
Location: Oxford, ENGLAND
Deadline: 26 May 2021

Applications are invited for a post-doctoral neuronal cell biologist to work on a research project at the Oxford Parkinson's Disease Centre (OPDC) to test therapeutic drugs to target HDAC4 in pre-clinical models of Parkinson’s funded by the Michael J Fox Foundation.

This is an exciting opportunity to work on a research project to validate novel therapeutics for PD focused on the modulation of HDAC4. This project will undertake target validation to better understand the molecular mechanisms of PD, and test new therapies by targeting HDAC4 in induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from PD patients and in mouse models.

Duties include design and implementation of experiments; interpretation of data; imaging analysis; differentiation and analysis of iPSC-derived neurons and cell lines; target engagement and phenotypic correction studies in mouse models; preparation of data for publication; contribute ideas for new research projects and develop ideas for generating research income; manage own academic research involving small-scale project management and act as a source of information to other members of the group.

You will have excellent practical experience of working with neuronal cell cultures, good knowledge of cellular and animal models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes.

The post is available from 01 July 2021 for 18 months, in the first instance. The post will be based in the Laboratory of Molecular Neurodegeneration, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX.

Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).

Closing date for applications is midday on Wednesday 26 May 2021. Interviews are likely to be held the week commencing Monday 06 June 2021.


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