Oxford-Janssen Postdoctoral Fellow

Updated: about 2 months ago
Location: Oxford, ENGLAND
Deadline: 27 Jan 2021

We have an exciting opportunity for a post-doctoral scientist to join the group of Professor Graham Ogg based in the MRC Human Immunology Unit at the MRC Weatherall Institute of Molecular Medicine as one of the first Oxford-Janssen fellows.

The Oxford-Janssen Cartography Consortium is a large, ambitious 3-year project that aims to provide insights into pathogenic pathways across immune mediated inflammatory disorders (IMIDs) to enable target identification, patient stratification, biomarker discovery and combination rationales. IMIDs are classified based on the organ system affected, however genetic association studies, functional studies, and clinical response to treatment with immunomodulatory medications, suggest that there is substantial mechanistic overlap between IMIDs. The consortium will create a cross-disease, cross-tissue cell atlas of IMIDs combining multi-omic single cell analysis, functional studies and clinical phenotyping across multiple IMIDs (gastroenterology, dermatology, rheumatology).

The post-holder will integrate with the other Cartography team members, in particular Professor Fiona Powrie, Professor Simon Travis and Professor Paul Klenerman, with a particular focus on translational relevance of immune responses in the skin. The post will involve collaboration with other research groups including Professor Chris Buckley, Kennedy Institute, Oxford and Professor Holm Uhlig, Translational Gastroenterology Unit. It is funded by Janssen.

As well as the overall activities, which will leverage single cell data from tissue of patients with different diseases, the postholder would be involved in functional immunological analyses including T cell and other relevant assays to explore underlying mechanism.  These activities will include ELISA, ELISpot, flow cytometry, T cell cloning, and numerous molecular biology approaches.  The initial immunological focus will likely be on the role of antigen-specific T cells in human skin inflammation with a strong emphasis on translation towards patient benefit. Although most of the hands-on single cell analysis would be undertaken by a bioinformatics team, the postholder would benefit from exposure to single cell data analysis across multiple different pipelines through state-of-the-art technologies.

To be considered for this position you should hold a relevant PhD/DPhil, (or close to submission) together with relevant experience. You should also possess sufficient specialist knowledge in the discipline to work within established research programmes, including flow cytometry, ELISpot, T cell culture, RNA seq

You must have a proactive and adaptable approach to work and willingness to collaborate. Excellent record keeping, careful methodological work skills and the ability to meet deadlines are essential. You will need to communicate effectively with a range of stakeholders, including the Oxford-Janssen management team and contributing groups across Oxford and Janssen.

This is a full-time fixed-term appointment for three years in the first instance.

You will be required to upload a CV and supporting statement as part of your online application.

Only online applications received before 12:00 midday on Wednesday, 27 January 2021 will be considered.

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