MRC Postdoctoral Research Scientist in Senescence in cancer and ageing LMS - 1576

Updated: about 2 months ago
Location: London, ENGLAND
Deadline: 14 Jun 2021

View Vacancy -- MRC Postdoctoral Research Scientist in Senescence in cancer and ageing LMS - 1576
Open Date
12/05/2021, 09:00
Close Date
14/06/2021, 23:55

MRC London Institute of Medical Science

The London Institute of Medical Sciences (LMS) at Hammersmith Hospital is the third directly funded MRC research institute and enjoys close links with its partners at Imperial College and at the Imperial College Healthcare NHS Trust. The LMS research focuses on strengthening the basic science underpinning our understanding of human diseases and the translation of such high quality research into a clinical setting.


UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org

MRC - 4

London

£32,302 - £35,143* plus London allowances (£3,727 & £1,402) per annum

Fixed Term

Science

Full Time

3 years

The post holder will be directly responsible to as well as work closely with Group Head, Prof Jesus Gil. The post holder is also expected to form good working relationships with members of the Senescence group.

 


Research background

Senescence is a stress response by which damaged or old cells implement and stable cell cycle arrest. Senescence is accompanied by specific phenotypic changes such as the production of a complex mixture of secreted factors (known as the senescence-associated secretory phenotype or SASP). Senescent cells accumulate during ageing and are also present in preneoplasic and fibrotic tissue. Recent research suggests that senescent cells influence multiple pathologies and the selective elimination of senescent cells can be used as therapy for these senescence-associated diseases. Our research programs aims at understanding the molecular mechanisms underlying senescence and its associated phenotypes. In general terms we are interested in understanding the molecular pathways regulating senescence and understanding the function of regulation of the SASP. This will provide a basis to develop strategies for the selective elimination of senescent cells. For more information about our research, please visit: https://lms.mrc.ac.uk/research-group/senescence/

 

Job Summary

This post provides an opportunity for a highly-motivated individual to be part of a project aiming to identify and characterize novel mechanisms regulating senescence and the SASP. The post is for 3 years and is being funded by Medical Research Council.

Main duties / key responsibilities

The specific duties of the post holder are as follows:

• To be able to conduct research in accordance to the project

• To actively contribute to the smooth running of the laboratory in co-ordination with other members of the group

• To form a good working relationship with other members of the group and actively participate in team work

• To design and carry out scientific experiments in accordance with the group projects

• To analyse, manage and communicate data, ensuring the validity and reliability of the data at all times

• To generate reagents for the group projects 

• To maintain organised and accurate records of experimental data

• To actively participate in the group’s research meetings and other research meetings related to the project

Other duties will include:

• To undertake appropriate administrative tasks as required

• To undertake any necessary training and/or development

 

Working relationships:

The post holder will work closely and be directly responsible to Professor Gil.



Education / Qualifications / Training required:

Essential:

  •  PhD (or equivalent)  in a Life Science or Biomedical discipline 
  • Being first author of a research paper already published or in press

Desirable:

  •  Home Office Personal Licence 

Previous work experience required:

Essential:

  • Experience in molecular biology (cloning, PCR, IF, IHC, etc).
  • Experience in cell biology

Desirable:

  • Experience in mouse work
  • Experience with genetic or drug screens
  • Experience with RNAi, CRISPR
  • Experience with lentiviral or retroviral expression systems
  • Experience with high throughout microscopy systems (such as InCell 2000)

Knowledge and experience:

Essential:

  • Ability to plan ahead and organise time effectively
  • Ability to accurately document work and keep clear records of the experiments being performed
  • Ability to design new lines of experiments
  • Ability to troubleshoot technical difficulties
  • Excellent analytical skills
  • Good working knowledge of standard software and scientific applications with basic concepts of statistics and bioinformatics

Personal skills/behaviours/qualities:

 Essential:

  • Strong attention to detail and focus on high quality work
  • Ability to work independently as well as collaboratively with other members of the group

Desirable:

  • Good written and verbal communication skills


Please upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification).

* Additional allowances comprise of a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the 1st  ear, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.


The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

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