Lead Scientist-Next Generation Sequencing

Updated: 2 months ago
Location: Oxford, ENGLAND
Job Type: FullTime
Deadline: 10 Feb 2021

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, JR Hospital, Headington, Oxford, OX3 9DS

Grade 7: £32,817- £40,322 per annum

Applications are invited for a post-doctoral research scientist to work in the Simmons laboratory based at the Weatherall Institute of Molecular Medicine at the University of Oxford. This is an outstanding opportunity to work on a newly funded project Immune Discovery in Gastrointestinal Disease. The objectives of the project are to understand the immune processes underpinning progression of gastrointestinal diseases including inflammatory bowel disease (IBD). Understanding mechanisms of gastrointestinal disease heterogeneity is our aim with a view to defining common pathways by which the immune system maintains intestinal health, fights infection or drives inflammation. The work involves an interdisciplinary team with expertise in functional genetics, cell biology, human molecular pathology and murine transgenic models. The successful candidate will be primarily responsible for generating a variety of next generation sequencing data to underpin discovery in molecular pathology of gastrointestinal disease.

For this position, we are seeking a highly motivated Scientist with expertise in genomics and next-generation sequencing. The successful candidate will be responsible for performing nucleic acid extraction, library preparation and sequencing (targeted panels, whole-exome, whole-genome sequencing, single cell and bulk RNA-sequencing, spatial transcriptomics, ATAC-seq and Capture-C) on samples from patient cohorts, with the objective of characterising the immune contribution to disease heterogeneity. The candidate will interact with other members of the lab, including computational scientists and bioinformaticians for the analysis of the data. The candidate will hold a relevant PhD/DPhil with post-qualification research experience, must have a biology background, experience with next-generation sequencing and be highly organised and meticulous. The successful candidate will work closely with a diverse team to formulate and validate hypotheses.

The post is full time, fixed-term, available for 24 months with the possibility of extension.

Informal enquiries can be made to Professor Alison Simmons on 01865 222628. Interviews will be held in the first weeks of March 2021.

Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application.

Only applications received before 12.00 midday on Wednesday, 10 February 2021.


Closing Date: 10-FEB-2021 12:00

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