Junior Researcher - Biology

Updated: about 2 months ago
Location: Oxford, ENGLAND
Job Type: FullTime
Deadline: 25 Apr 2021

Junior Researcher - Biology

Nucleic Acid Therapy Accelerator (NATA)

The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), are investing a total of £30m to establish a new research centre, the nucleic acid therapy accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid drug delivery, through focused NATA research challenges and a NATA infrastructure hub. This is an internationally unique resource, drawing on world-leading academic expertise in partnership with innovative businesses to discover and test viable ways of delivering oligonucleotide therapies, anchoring the oligonucleotide therapy industry in the UK for many years to come. 

The Role

The Junior Researcher will be critical in supporting the NATA biology department by developing new techniques and methods related to the assessment of delivery, toxicity and efficacy of Acid Nucleic Therapeutics in multidisciplinary projects. This individual will be involved in the development of new techniques and methods for 1) the quantification and localization of Nucleic Acid Therapeutics after administration in vitro and in vivo, 2) the mechanism of uptake of New Nucleic Acid Therapeutic, 3) the assessment of clearance and pharmacokinetic parameters associated to Nucleic Acid Therapeutics. This position will also include biological validation of novel Nucleic Acid Therapeutics conjugates using already established protocols.

The post holder will manage the biology side of Nucleic Acid Therapeutics projects for various collaborations. They will report to the Head of department.

Essential selection criteria

    Hold a relevant Ph.D/D.Phil in biology, pharmacology, toxicology or a related discipline

    Experience in one or more of the following areas: RNA library preparation and sequencing, fluorescence microscopy/image analysis (including sample preparation) or FACS analysis.

    Experience with Nucleic Acid therapeutics including antisense and RNA interference would be an advantage

    High level of creativity and independence in developing innovative analysis methods and solving complex problems

    High level organisational skills, with the ability to manage a broad range of projects simultaneously and under pressure.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

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