Research Associate

Updated: 19 days ago
Location: Cardiff, WALES

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Research Associate
Cardiff School of Biosciences


A position is available in the Dafydd Jones group at Cardiff Universty’s School of Biosciences in collaboration with Oliver Castell (School of Pharmacy and Pharmaceutical Sciences) and Matteo Palma (Queen Mary University of London) on a project that uses cutting edge protein engineering to interface proteins with carbon nanotubes for constructing next generation ultra-sensitive biosensors.

The successful candidate will have a postgraduate degree at PhD level (or nearing completion / submission) in protein biochemistry/chemical biology or relevant industrial experience, knowledge of current status of research in specialist field and an established expertise and proven portfolio of research and/or relevant industrial experience within of the following research fields:


i. Protein engineering and associated molecular techniques (mutagenesis, cloning, molecular analysis of proteins, recombinant protein production).
ii. A good working knowledge of protein chemistry or chemical biology, including bioconjugation


This position is full-time, and fixed term for 10 months available form 16th November 2020.


Salary: £33,797 - £40,322 per annum (Grade 6). Please note that it is not expected that we will appoint above grade 6.30, currently £33,797 per annum.


Date advert posted: Friday, 23 October 2020

Closing date: Monday, 9 November 2020

This post has previously been advertised to employees of Cardiff University only.  We now invite external applications.



Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds.  We therefore welcome applicants from all sections of the community regardless of sex, ethnicity, disability, sexual orientation, trans identity, relationship status, religion or belief, caring responsibilities, or age.  In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.


Job Description

To conduct research focusing on protein engineering for nanoscience and to interact with researchers from other disciplines. To carry out research with the aim to publishing work in high quality journals and/or generate data for patent filling. To pursue excellence in research with integrity and to inspire others to do the same.


Research

* To conduct research within the are of protein engineering, recombinant protein production, protein molecular analysis and bioconjugation with a specific focus on its application to nanosciences and biosensors
* To interact and liaise with researchers within the University, notably the School of Pharmacy and Pharmaceutical Sciences and School of Physics and Astronomy.
* To interact and liaise with partner researchers at Queen Mary University of London.
* To contribute to the overall research performance of the School and University by the production of measurable outputs including publishing in national academic journals and conferences, and the supervision of postgraduate research students.
* To travel/meet online with partner institutions outside of Cardiff.
* To undertake administrative tasks associated with the research project, including the planning and organisation of the project and the implementation of procedures required to ensure accurate and timely reporting
* To prepare research ethics and research governance applications as appropriate
* To review and synthesise existing research literature within the field
* To participate in School research activities.
* To build and create networks both internally and externally to the university, to influence decisions,   explore future research requirements, and share research ideas for the benefit of research projects


Other

* To engage effectively with industrial, commercial and public sector organisations, professional institutions, other academic institutions etc., regionally and nationally to raise awareness of the School’s profile, to cultivate strategically valuable alliances, and to pursue opportunities for collaboration across a range of activities. To undergo personal and professional development that is appropriate to and which will enhance performance.
* Any other duties not included above, but consistent with the role.


Person Specification


IMPORTANT NOTE: When submitting your supporting statement, you must provide evidence as to how you meet each of the essential (and desirable if applicable) criteria below. We suggest that you do so by using each of the criteria as sub-headings, providing written evidence of your relevant skills underneath. Before uploading this attachment, please ensure that you include 10453BR within the filename.
Essential Criteria
Qualifications and Education

1. Postgraduate degree at PhD level (or nearing completion / submission) in protein biochemistry/chemical biology or relevant industrial experience


Knowledge, Skills and Experience

2. An established expertise and proven portfolio of research and/or relevant industrial experience within the following research fields:

i. Protein engineering and associated molecular techniques (mutagenesis, cloning, molecular analysis of proteins, recombinant protein production).
ii. A good working knowledge of protein chemistry or chemical biology, including bioconjugation

3. Knowledge of current status of research in specialist field
4. Proven ability to publish in reputed journals.
5. Knowledge and understanding of competitive research funding to be able to develop applications to funding bodies


Communication and Team Working

6. Proven ability in effective and persuasive communication
7. Ability to supervise the work of others to focus team efforts and motivate individuals


Other

8. Proven ability to demonstrate creativity, innovation and team-working within work

9. Proven ability to work without close supervision


Desirable Criteria

10. A working knowledge of general protein engineering approaches including directed evolution and non-natural amino acid incorporation
11. A working knowledge of single molecule analysis approaches such as AFM and fluorescence (e.g. TIRFM)
12. A strong interest in structural biology, in silco protein design and biophysical analysis, especially with relation to protein-protein interactions.
13.  Proven ability to adapt to the changing requirements of the Higher Education community.
14. Evidence of ability to participate in and develop both internal and external networks and utilise them to enhance the research activities of the School.


Additional Information

The merging of biology with nanoscience opens up new opportunities to improve our fundamental knowledge and the generation of technologies to improve our everyday lives. As proteins are Nature’s own nanomachines and processing devices, there has been a push to use them as active components in a range of nanotechnological areas, including miniaturised biosensors. The advantage of these biosensors is that they are more sensitive than many other methods and therefore able to detect very tiny quantities of proteins of interest, even down to the single molecule level. This will allow earlier and more accurate diagnosis of disease such as infections, cancer or dementia. To realise their full potential, we need to address one of the central challenges in nanobiotechnology: assembling the components in a defined way. You will do this using expanded genetic code approaches to introduce new and useful chemistry into a target protein at defined residues so as to precisely interface protein with nanotube. Your project will focus on developing biosensors that under disease with a focus on antimicrobial resistance. However, there are opportunities to expand the idea to generate new biosensing approaches to address COVID19. Thus, the position is ideally suited to an individual with a background in protein engineering and protein chemistry/chemical biology.


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