Experimental Postdoctoral Fellow

A position is now available for a highly motivated Postdoctoral Fellow to join the research group of Ana Cvejic, Peter Campbell and Open Targets partners at the Wellcome Sanger Institute (WSI).

Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness   of   pharmacological   intervention   on   these   targets, using   genome-scale   experiments   and   analysis.   This   pioneering public-private   partnership   between   Sanofi, Celgene, EMBL-EBI, GlaxoSmithKline, and   the   Wellcome   Sanger   Institute,   aims   to provide  a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community(http://www.opentargets.org ).

The project will combine state-of-the-art single-cell data generation with spatial transcriptomics to study the spatial distribution of diverse immune cells in cancer, and discover putative cell-cell interactions across the tumour microenvironment.

You will have a PhD with significant experience in molecular and cell biology. Knowledge in the field of immunology, cancer biology and inflammation would be highly advantageous. You will be able to demonstrate critical thinking, will be hard working, passionate about science, and keen to learn and improve skills in a supportive research environment. You will be part of a multidisciplinary team and will be tasked with proactively seeking and maintaining appropriate collaborations. You will also be expected to drive forward the project, working closely with biologists, clinicians and bioinformaticians within and outside the group to accomplish scientific objectives.

This position could be based at the Wellcome Sanger Institute or at the University of Cambridge in Ana Cvejic's lab.

• PhD in immunology, cancer biology, biological sciences (or similar) 
• Extensive experience in a research environment with a well-established publication track record 
• Demonstrable ability to lead the projects 
• Extensive experience in flow cytometry and cell culture

Behaviours and Competencies:

• Highly organised 
• The ability to effectively communicate with collaborators and occasionally present oral communication to large groups 
• Demonstrates inclusivity and respect for all 
• Ability to manage own workload 

• Experience in working with patient-derived material 
• Experience with CRISPR screening 

Please apply with your CV and a cover letter outlining your suitability for the role addressing the criteria set out above and in the job description.

Open Targets is a pioneering public-private partnership between European Bioinformatics Institute (EMBL-EBI), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Sanofi and Bristol Meyers Squibb (BMS), located at the Wellcome Genome Campus in Hinxton, near Cambridge, UK.  

Open Targets brings together expertise from five complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease to improve the success rate of discovering new medicines and share data openly in the interest of accelerating drug discovery.