Details
Title: Developing gene therapy approaches for CADASIL.
Description:
Join us in pioneering cutting-edge research to develop innovative therapies for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). CADASIL is a devastating genetic disorder characterised by recurrent strokes, cognitive decline, and other neurological symptoms, with no definitive treatment currently available.
At the University of Sheffield, our multidisciplinary research team is dedicated to advancing therapeutic strategies for CADASIL. Led by renowned experts in neurology, molecular medicine, and gene therapy, our project aims to revolutionise treatment options for this debilitating condition.
Our approach focuses on harnessing gene therapy to target and modulate the expression of the NOTCH3 gene, which is implicated in CADASIL pathogenesis. The research will involve comprehensive preclinical studies to assess the efficacy and safety of gene therapy in cellular and animal models of CADASIL. Through meticulous experimentation and molecular analysis, we aim to elucidate the underlying mechanisms of gene therapy and optimise treatment protocols for future clinical translation.
In addition to our innovative research endeavours, our project prioritises collaboration and knowledge exchange. We actively engage with clinicians, geneticists, and NIHR to ensure that our research is clinically relevant and patient-centred. By fostering a collaborative ecosystem, we aim to accelerate the development and dissemination of effective therapies for CADASIL.
As a PhD student on this project, you will have the opportunity to contribute to groundbreaking research at the forefront of neurogenetics and precision medicine. Under the guidance of experienced mentors, you will develop expertise in molecular biology, gene therapy, and translational research, while making meaningful contributions to the scientific community.
We are seeking motivated and enthusiastic candidates with a background in biomedical sciences, genetics, or related fields. Candidates should demonstrate a passion for research, strong analytical skills, and the ability to work effectively in a collaborative team environment.
Join us in our mission to transform the landscape of CADASIL treatment and improve the lives of patients affected by this devastating disease. Together, we can make a profound impact on the future of neurogenetic medicine.
If you are interested in this project, please contact Dr Favour Felix-Ilemhenbhio ([email protected])
Entry Requirements:
Candidates must have at least a first or upper second-class honours degree. A master’s degree or relevant experience in gene therapy is preferred.
How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply
Please clearly state the prospective main supervisor in the respective box and select Neuroscience as the department.
Enquiries:
Interested candidates should in the first instance contact Professor Majid ([email protected])
Funding Notes
The Faculty of Health is accepting applications for the University of Sheffield Research Scholarships for Black or Black British (of African or Caribbean heritage), Asian or Asian British (of Bangladeshi, Pakistani and Indian heritage) or multiple ethnic backgrounds including one of the ethnicity groups listed above.
The University of Sheffield is committed to increasing opportunities in doctoral research for particular minoritised students who are currently under-represented in our postgraduate research student population.
Candidates will be required to complete a declaration form and upload it to their application. Applicants with overseas fee status are NOT eligible for these awards.