Research technician position: Investigating brain aging through in vivo CRISPR screens

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100%, Basel, fixed-term

The Laboratory for Biological Engineering (Prof. Randall J Platt) at ETH Zurich in Basel develops genome engineering technologies and applies them to a range of fundamental and disease-focused areas (www.platt.ethz.ch ). To advance these efforts we are seeking a full-time research technician with expertise in mouse models, viral vectors, deep sequencing library preparation, and molecular and cellular biology.

Job description

We are looking for a research technician to join our multidisciplinary team of scientists and work on a project focused on gaining insight into brain aging and neurodegeneration through the use of in vivo CRISPR screens. The candidate will be passionate about science, technology and communication.

Your profile

• The ideal candidate should have a Ph.D. or equivalent in Molecular and Cellular Biology, Biochemistry, Neuroscience, or a related field.
• The candidate must have extensive experience working with animals (FELASA, category B or LTK module 1) including husbandry, tail vein injection, perfusion, tissue isolation, processing and histology, as well as using a range of molecular and cellular methods, including standard molecular biology techniques (plasmid preparation, molecular cloning, qRT-PCR/ddPCR) and mammalian cell culture.
• Prior experience with virus production and preparation of deep sequencing libraries for functional genomics experiments is a major plus. Prior experience with extraction of DNA or RNA from mouse tissue, immunofluorescence and flow cytometry is a plus.
• Mastery of oral and written English and the ability to communicate effectively in a highly interdisciplinary and international environment are required.

ETH Zurich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

Working, teaching and research at ETH Zurich