Research Assistant - Cellular and Molecular Biology

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100%, Zurich, fixed-term

The Genome Engineering and Measurement Lab (GEML) develops, implements, optimises, and analyses cutting edge genome engineering tools and techniques supporting a wide range of research projects at ETHZ, UZH and the USZ. As part of our collaboration with Prof. Corn’s Lab of Genome Biology, and newly secured EU-Horizon funding, we are seeking a Research Assistant with expertise in Cellular and Molecular Biology to join our team.

The Genome Biology and the Genome Engineering and Measurement Labs are part of ETH Zürich. We are located in the Institute of Molecular Health Sciences at the ETHZ Hönggerberg campus. Our overarching goal is to deploy tools that can target unique genomic sites with the high activity and specificity required for in vivo and in vitro applications, such as gene and cell therapy, and diagnostics. We work in a fast-moving field, ensuring a thrilling environment. The Research Assistant position is initially for 12 months and extendable for up to a maximum of four years.

Job description

Your field of activity will essentially include:

• Mammalian cell culture (cell lines and primary cells)
• Cell editing and editing analysis
• Molecular biology, such as PCR, qPCR, ChIP, NGS library preparation
• Preparation and validation of diverse CRISPR/Cas reagents
• Assistance with general lab duties (e.g. organisation tasks)

You will be responsible for testing and comparing the On- and Off-target activity of different CRISPR/Cas tools in human cell lines and primary cells. Furthermore, as a research assistant you will work together with a small team of other technicians, graduate students, and senior scientists to profile genome engineering reagents in different cellular contexts and analyse samples provided by our European partners. The primary EU-Horizon projects will be pre-clinical in nature, and your work will directly impact potential therapies for multiple genetic disorders.

Your profile

You are very well organised and able to work efficiently and with precision in a fast paced environment. You are proactive and can work independently but also as part of a small group. You can use computer software to manage, analyse, and share information. Advanced knowledge of English is essential, as this is the working language of the team.

Required skills:

• Molecular Biology or similar discipline qualification (e.g. B.Sc. degree or equivalent) with at least 3 years professional experience in industry or academia
• Expertise with standard molecular biology techniques
• Mammalian cell culture experience

Preferred skills:

• Experience with applying CRISPR/Cas or other genome engineering tools

Desired skills:

• Experience with NGS library preparation protocols
• Experience with Off-target Identification workflows

ETH Zurich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

Working, teaching and research at ETH Zurich