Principal Scientist - Oncology Research (80-100%*)

Updated: over 1 year ago
Job Type: FullTime
Deadline: The position may have been removed or expired!

6000+! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

With Novartis expanding its horizons in the field of targeted radioligand therapy (RLT), the Oncology department at NIBR is looking for a PhD level Principal Scientist with a strong background in cancer cell biology. Expertise in the field of radiobiology and/or DNA Damage Repair would be desirable.

The candidate will join the Oncology Translational Research group located in Basel, Switzerland, and will be responsible to lead a laboratory and projects aimed at supporting the clinical development of cancer therapeutics including radioligand therapies, as well as increasing the mechanistic understanding of targeted radioisotope-based therapies.

This is an excellent opportunity to join a world class research team at NIBR in Basel, Switzerland.

Through a broad and deep knowledge of cancer biology and in collaboration with peers within the team, the candidate is expected to develop ideas and conduct experiments to understand and validate the effect of radiation caused by radioligand conjugates on various cellular functions including DNA damage repair (DDR) and cell fate, discover combination therapy opportunities, identify molecular predictors of response to cancer therapies and to investigate resistance or survival mechanisms in presence of such drugs.

Amongst others, your role will be to define and implement cutting-edge experimental strategies, to produce high quality data to validate concepts, and to translate scientific insights into clinical development strategies in collaboration with the respective project teams. To achieve this, state-of-the-art, hands-on molecular and cell biology experience, as well as proficiency in leveraging and utilizing bioinformatics infrastructure and tools will be required to perform in the role. Strong collaborative team spirit, excellent communication skills and willingness to pro-actively interact across the global organization will be essential to succeed in the role. Excellent mentoring and coaching skills will be a necessary asset to develop lab members scientifically and professionally.

Your responsibilities will include:

• Define and execute best experimental strategy to deliver interpretable data to test hypotheses, address scientific questions and progress projects
• Perform lab work (in vitro) to deliver the highest quality of experimental science
• Guide, supervise and develop scientific research associates, as well as manage lab resources in a flexible manner to adapt to changing priorities
• Contribute to drug discovery and clinical development projects within multidisciplinary teams
• Develop novel ideas and concepts aimed at identifying optimal ways to use cancer drugs, including RLTs/radioligand therapies in patients
• Present concepts and projects in a clear, scientifically sound / data-driven and objective manner in different settings and venues
• Closely work with multiple teams across expertise groups within Oncology and across departments in the global organization



Similar Positions