Postdoctoral research position, functional dependency mapping in very…

Postdoctoral research position, functional dependency mapping in very high risk acute lymphoblastic leukemia (ALL)

High resistant acute lymphoblastic leukemia can be classified in distinct molecular subtypes, often driven by oncogenic events that control transcriptional and epigenetic regulation of gene expression. This project focuses on functional dependency mapping of defined VHR-ALL subtypes and the characterization of the molecular pathways that are essential for leukemia resistance to current therapy.  These include TCF3-rearranged ALL (TCF3-HLF positive ALL and relapsed TCF3-PBX1 ALL), among others. Understanding the driver mechanism of the oncogenetic transcriptional program is key for the development of more effective therapy.

Your responsabilities

·       Contribution to establishing a functional genomic program based on representative patient derived xenograft of TCF3-rearranged ALL

·       Identification of direct transcriptional targets and functional evaluation based on NGS and HiC data

·       Evaluation of actionable targets with ex-vivo and in vivo models 

·       Contribution to our functional precision hematology oncology program to propose personalized treatment options for these patients at unmet clinical needs.

Your profile

·       You hold an MD-PhD or PhD in biological or biomedical sciences or equivalent 

·       You bring a solid background in molecular genetics and interest in bioinformatics.

·       You have a strong interest in cancer and systems biology 

·       You have strong analytical and organization skills. You are comfortable with planning and have a cooperative mindset

·       You have excellent verbal/written communication and interpersonal skills with proficiency in English

·       You are motivated to work together in task forces and to guide master as well as PhD students.

About the Leukemia Research Group

·       Laboratory located at the research campus Lengg of the University of Zurich

·       State-of-the-art technologies including single cell analytics, CRISPR-based genome editing, machine learning, high-throughput data analysis and ex-vivo / in vivo PDX models

·       Strong pediatric precision oncology program and network with UZH, ETH Zurich and leading international cooperation partners

·       Pioneers in clinical precision hematology oncology.

Position

Postdoctoral position secured for two years, can be extended