Postdoc Position - Contribution of Cell Size to Cell Function in Multicellular Systems

100%, Zurich, fixed-term

Why do cells control their size and how is it possible that different cells in our body vary 1000 fold in size and can still function? We are looking for a new member to join our team to study these fundamental questions.

Project background

From bacteria to eukaryotes all cells of a specific type have a characteristic size. Size homeostasis is therefore a universal feature of cells. Deviations from normal size coincide with altered cell function during pathological processes, such as cell senescence or cell transformation, suggesting that having a defined size is critical for optimal function. This optimal size can however vary: Unicellular organisms adjust their size to environmental conditions and within the same multicellular organism different cell types can have vastly different sizes. Cell size is therefore tightly regulated but can vary substantially. Our lab is interested in understanding why it is important for cells to have a specific size and how changes in cell size contribute to altered function during cell senescence and differentiation. For this purpose, we use a combination of genetics, live cell microscopy and quantitative transcriptomics and proteomics approaches in budding yeast and mammalian systems.

Job description

The advertised project aims at understanding how naturally occurring changes in cell size contribute to altered cell function in multicellular organisms. To this end, you will establish an in vitro model system to manipulate cell size changes during differentiation and describe how this affects key parameters such as overall proteome composition, nuclear function and differentiation.

Your profile

We are looking for a curious, pro-active mind who is motivated to study fundamental biological questions. You should bring:

• PhD in Cell Biology, Molecular Biology or equivalent
• Ample experience with tissue culture
• Experience in chromatin analysis, 3D cell culture or differentiation assays would be a plus
• Excellent communication skills in English
• Willingness to work as part of a team

Your workplace

Your workplace

We offer

ETH Zurich is one of the world’s leading universities specialising in science and technology. We offer the possibility to work with an international team of young scientists in this vibrant research environment, an ideal place excell and launch the next step in your career.

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Curious? So are we.

We look forward to receiving your online application with the following documents:

• Letter of motivation
• CV
• Contact details of two referees

Applications will be considered on a rolling basis until a suitable candidate is found. For questions regarding the position please contact Gabriel Neurohr .

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.