80%-100%, Zurich, fixed-term
The Institute of Molecular Systems Biology at ETH Zurich is inviting applications for a Postdoctoral position in the group of Professor Dr Nicola Zamboni .
Project background
The group of Prof. Zamboni has a long history in the development and use of tracing experiments for the analysis of cellular metabolism. The approach relies on the supplementation of isotopically labelled metabolites. These include stable isotopes (e.g. 13C, 2H), whose structure gets scrambled under the action of metabolism. If appropriately designed, the resulting labelling patterns indicate the activity of intracellular metabolic pathways and reactions. Quantitative information about fluxes is obtained by measuring the labelling patterns by mass spectrometry and by mathematical inference with a model that accounts for all possible atomic transitions. However, to date, the adoption of tracer studies by non-expert groups is hindered by the often prohibitive need for expertise and technical means.
The Zamboni lab is aiming at simplifying tracer studies for clinical applications. While most elements of the workflow have been established over the past decades, the challenge is to assemble all pieces in an integrated and automatised workflow to support routine analyses. The project demands the integration of experimental and computational developments. This position covers the computational and IT work of the project. Beyond mere flux estimation, the tasks include all the elements essential to automatise the whole workflow, from raw mass spectrometry data to reporting of results. Developments will be defined and verified in regular meetings with stakeholders from clinical and research labs. The initial appointment is for two years.
Job description
You will lead all computational activities necessary for estimating fluxes from MS data, including the optimal design of tracers and LC-MS assay. Furthermore, you will integrate means for quality control and quality assurance of input data, as well as build user-friendly interfaces for data submission and reporting. Implementing computational modules systems in containers for automated deployment on local or cloud infrastructure will also be a duty of your job.
You will cooperate and communicate tightly with colleagues and clinicians performing the experiments to identify and remove bottlenecks and bugs. Foster open communication with team members, stakeholders, and potential users. You always aim for the highest quality of service for end users and you will roll out software releases regularly for testing.
Your profile
- Doctoral degree in computer science, bioinformatics, applied mathematics or equivalent.
- Ample experience in machine learning, Bayesian statistics, and possibly simulation-based inference.
- Deep understanding of the mathematical paradigms used to calculate fluxes from mass spectrometry data (e.g. refs 1 , 2 , 3 , 4 ). Practical experience on this topic is considered a differentiating asset.
- Experience with building and deploying containers, workflow managers (e.g. snakemake and nextflow), application servers, and data visualisation is advantageous.
- Passion for metabolism, ambition to impact clinical practice, and entrepreneurial spirit.
- Proactive, solution-oriented attitude and excellent communication skills.
Your workplace
Your workplace
We offer
ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.
chevron_right Working, teaching and research at ETH ZurichWe value diversity
In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our
Equal Opportunities and Diversity websiteto find out how we ensure a fair and open environment that allows everyone to grow and flourish.
Curious? So are we.
We look forward to receiving your online application with the following documents:
- CV
- A motivation letter stating own visions and specifying any past experience that is aligned with the job profile.
- Name and contacts of two referees
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Further information about the Institute of Molecular Systems Biology can be found on our website . Questions regarding the position should be directed to Dr Nicola Zamboni, email [email protected] (no applications).
About ETH Zürich
ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.
Similar Positions
-
Postdoctoral Researcher In The Field Of Microscale Robots, ETH Zürich, Switzerland, 30 days ago
19 Mar 2024 Job Information Organisation/Company ETH Zürich Research Field Engineering » Other Technology » Nanotechnology Researcher Profile Recognised Researcher (R2) Country Switzerland Applica...
-
Postdoc Positions In Experimental Quantum Engineering Group, ETH Zürich, Switzerland, about 8 hours ago
18 Apr 2024 Job Information Organisation/Company ETH Zürich Research Field Physics » Optics Physics » Other Researcher Profile First Stage Researcher (R1) Country Switzerland Application Deadline ...
-
Two Postdoctoral Positions In The Electrochemical Energy Systems Laboratory, ETH Zürich, Switzerland, about 8 hours ago
18 Apr 2024 Job Information Organisation/Company ETH Zürich Research Field Chemistry » Other Researcher Profile Recognised Researcher (R2) Country Switzerland Application Deadline 15 Jul 2024 - 21...
-
Eiermann Postdoctoral Fellowship, ETH Zürich, Switzerland, about 1 month ago
19 Mar 2024 Job Information Organisation/Company ETH Zürich Research Field Architecture » Design Architecture » Other History » Modern history Researcher Profile Recognised Researcher (R2) Country...
-
Postdoc Position In Experiment Guided Computational Neuroscience, ETH Zürich, Switzerland, 14 days ago
4 Apr 2024 Job Information Organisation/Company ETH Zürich Research Field Biological sciences » Biology Mathematics » Computational mathematics Neurosciences » Other Researcher Profile Recognised ...
-
Postdoctoral Or Senior Researcher In Carbon Strategies And Innovations, ETH Zürich, Switzerland, about 1 month ago
19 Mar 2024 Job Information Organisation/Company ETH Zürich Research Field Engineering » Other Political sciences » Public policy Political sciences » Other Researcher Profile Recognised Researche...