PostDoc Position for the Project: Gene Engineering Macrophages for Cancer Immunotherapy

Updated: 2 months ago
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich
PostDoc Position for the Project: Gene Engineering Macrophages for Cancer Immunotherapy
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We have a very active program in experimental HIV medicine, in particular immunotherapy and gene engineering an HIV resistant immune system, and in gene-engineering monocytes/macrophages to fight cancer. We use all kinds of in vitro and in vivo methods. Ultimate goal is to translate our projects to application.
The laboratory of Prof. Speck is very well embedded in the research place of Zurich and benefits from its unique scientific richness. Notably, we have very active international collaborations for the gene engineering part (Prof. Michael Pepper, University of Pretoria (SA) and Prof. Karl-Heinz Krause, University of Geneva (CH)), for studying IFNs (Prof. Gideon Schreiber, Weizmann Institute of Science, Israel) and for immunotherapy (Prof. Giuseppe Pantaleo, University of Lausanne and Prof. Renata Stripecke, University of Hannover).
The laboratory is well financed by various foundations, among others by the Swiss National Science, Swiss Vaccine Institute, the VonTobel Foundation and the USZ Foundation.
Your responsibilities
We are looking for highly motivated person as PostDoc for our project: "Gene Engineering Macrophages for Cancer Immunotherapy". Thus we need a person capable working mainly on the molecular biology part of the project e.g. designing and improving lenitiviral vectors, chimeric receptors and evaluating the engineered macrophages in in vitro experiments and, in teamwork together with another PosDoc, in vivo. The desired profile is listed below. The project is related to "Human chimeric antigen receptor macrophages for cancer immunotherapy" (M. Klichinsky et al., 2020), but looking it from a different angle. Please note, the project is a high risk, high gain project with the medium to longterm goal of applying the developed therapy to the clinics.
We can only consider applications from European residents.
Your profile
  • PhD in molecular cell biology, immunology, cancer biology and immunotherapy
  • Expert on tumor microenvironment esp. tumor associated macrophages
  • Cell-based assays such as tumor in vitro models and phagocytosis assays
  • Strong background in molecular cell biology techniques
  • High-content confocal micropscopy
  • Multi-parameter flow cytometry
  • Experience with viral vectors for gene therapy/ immunotherapy (lentivirus, AAV) or non-viral transduction methods

  • Experience with in vivo cancer models especially with humanized mouse models
  • Experience in state of the art cloning techniques (Golden Gate; Gibson, Gateway)
  • Experience in viral vector production in suspension cell culture and viral particle purification and concetration

What we offer
The University Hospital of Zurich offers a future-oriented work environment with attractive employment conditions. The position is financed by third-party funds and foreseen for three years.
Place of work
University Hospital of Zurich - Lab is located in Wagistr.18, 8952 Schlieren
Start of employment
01. November 2022
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