Senior Lab Manager to the Department of Microbiology, Tumor- and Cellbiology

The Center for Translational Microbiome Research (CTMR) studies the role of the microbiome in human health with a focus on diseases of the gastrointestinal tract, women's health and reproduction, and cancer. The center is based on knowledge in microbiology, clinical epidemiology, gastroenterology and genomics. Over the past 4 years, an infrastructure has been built for large-scale DNA / RNA extraction and sequencing of human samples. We are now expanding with activities in the cultivation and characterization of microbes on a large scale for later development of medical products for individuals with disturbed normal flora. We collaborate with clinical researchers in a number of specialist areas where the connection between the microbiome and disease development is central.

The candidate is expected to perform research and development work in molecular microbiology. The position entails work both as part of a research and product development pipeline that requires adherence to GLP/pre-GMP protocols.

The main tasks of the applicant include the following:

• FACS sorting of bacteria and immune cells
• Sequencing (DNA/RNA) of bulk and single cell using MGI and Illumina technology
• Apply different techniques of DNA/RNA and protein extraction to optimize depending on sample type
• Bacterial and mammalian cell culture
• Automation of extraction and sequencing using robotic platforms such as Tecan and MGI (requires knowledge of setting up scripts for these automated platforms)
• Fluorescent in situ hybridization (FISH) imaging applied to bacterial cells
• Bioinformatics expertise for analysis and integration of multi-omics data (including metagenomics, metatranscriptomics, metaproteomics and metabolomics). Thus, knowledge of the following languages is required: Python, R, Matlab.

The successful applicant will also be helping the team leader to organize, document and check the purity of samples for product development. Work will also include handling of strict anaerobic bacteria and a working knowledge, or interest to take on, of anaerobic culturing technology is a must.

To qualify, the applicant must meet the qualifications for the duties specified above. An in-depth understanding of molecular microbiology and at least five years of experience is necessary to perform the routine work.We prefer candidates with a PhD degree (or an equivalent foreign qualification) and documented research experience in research and development work.

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Welcome to apply at the latest 19/7 2021

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.