Senior Lab Manager

The Simon research group is studying regeneration processes in aquatic salamanders. Natural examples of regeneration, such as salamanders, may unravel novel strategies for cell replacement of damaged or lost tissues. We study regeneration mechanisms in an aquatic salamander, the newt, which has the widest repertoire of regenerative abilities among tetrapods. During the past decade our laboratory has developed several methods, which has made these outstanding questions experimentally tangible. We place our findings on newt regeneration into an evolutionary context and test our results in a variety of mammalian in vivo and in vitro assays. The main target tissue of our investigations in the context of limb  regeneration is skeletal muscle. Skeletal muscle can contribute to limb regeneration in two ways, either by activation of quiescent stem cells or by dedifferentiation of differentiated muscle fibers. By various cell tracking strategies, we try to compare these two processes to each other in terms of their relative contribution to the limb. We also characterize molecular processes involved in the generation of limb progenitors from skeletal muscle.

The successful applicant will focus on limb regeneration using state of the art cell and molecular biological tools and will be involved in developing new methodologies. It will be important to collaborate with other members of our team with overlapping projects.

To qualify the person must hold a PhD degree and who is experienced in limb regeneration studies in vertebrates. The person should have proved skillfulness by authoring scientific papers in peer reviewed journals. Long term experience of work with non-vertebrate and vertebrate regeneration models, particularly Pleurodeles Waltl is an important merit.

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna 

The application is to be submitted through the Varbi recruitment system. In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.