Research Specialist in Reproductive Endocrinology and Metabolism and Computational Biology

The research at our lab The Reproductive Endocrinology and Metabolism at the Department of Physiology and Pharmacology aims to yield new key information on the pathophysiology of polycystic ovary syndrome (PCOS). PCOS is linked to multiple severe health consequences, including reproductive, metabolic, and psychiatric disorders. The research is translational, and in collaboration with others, we combine register-based, cross-sectional, and longitudinal clinical studies with different mice models.

The group works in an inspiring and interactive research environment in Biomedicum at Campus Solna (see https://staff.ki.se/biomedicum-for-staff ) and has on-going collaborative projects with national and international colleagues.

The group combine in vivo and in vitro clinical, and mice experiments with single cell RNA-seq of collected tissues. The applicant is expected to lead project of single-cell sequencing of human tissue. The applicant will also be involved in mice projects investigating how transgenerational transmission of PCOS occurs by dissecting molecular mechanisms of epigenetic inheritance and causal links. 

We are looking for a passionate, highly motivated researcher with a PhD degree in reproductive endocrinology and metabolism, molecular biology, or computational biology.

We expect the candidate to be involved in our comprehensive characterization of human tissue of women with and without PCOS with single cell RNA-seq and spatial transcriptomic analyses. Experience in handling human tissue samples and perform in vitro culture of human primary tissues is a strength. Moreover, a strength is if you have experience also from in vivo animal work including reproductive and metabolic phenotypic testing of mice.

Priority will be given to the applicant with proven ability to work independently. The person should be a positive team player and will be involved in supervision of master, PhD students as well as postdocs in the group. Moreover, good communication skills and good proficiency in spoken and written English are necessary and Swedish is a strength.

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

We expect the candidate to have a strong scientific background with relevant expertise in single cell biology with particular focus on RNA-seq, single cell RNA-seq and spatial transcriptomic analyses. Experience in handling human tissue samples and perform in vitro culture of human primary tissues is a strength. Moreover, a strength is if you have experience also from in vivo animal work including reproductive and metabolic phenotypic testing of mice, Crispr/Cas genome editing.

Priority will be given to the applicant with proven ability to work independently. The person should be a positive team player as postdoc in part will be involved in supervision of master, PhD students as well as postdocs in the group. Moreover, good communication skills and good proficiency in spoken and written English are necessary and Swedish is a strength.

It is particularly meritorious that the applicant has shown

• Proven experience in library preparation of single cell RNA-seq
• Data QC, data management and archival storage
• Analysis of large datasets, preparation of codes, development of new methods/tools for advanced analysis of datasets

It is meritorious that the applicant has shown

• Experience of supervising master students

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Biomedicum, Campus Solna

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latestJanuary 10th, 2024.

The application must be submitted through the Varbi recruitment system.