Research Specialist in molecular modeling and simulations

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet in Solna conducts research and teaching in immunology, infectious biology, cell biology and cancer. MTC has more than 400 active employees, consisting of, among others, doctoral students, postdoctoral fellows and professors. Our keywords are interdisciplinary, clinically based basic research and national and international cooperation.

We are looking for a scientist with a long-term experience working in the area of multi-scale molecular modeling and simulations of biomolecular systems. The researcher will drive the computational aspect of the research work in a multi-collaborative project that aims to characterize, and target protein molecules involved in oncology for potential anti-cancer therapeutics. The researcher will be responsible for the development of computational strategies to resolve challenges ranging from understanding biological observations by providing mechanistic insights to developing testable hypothesis through design experiments. The researcher will also be responsible for the monitoring, evaluation and completion of assigned tasks involved in the project.

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

• Long-term experience with molecular modeling and simulation techniques.
• Extensive experience in computational macrocyclic peptide design.·
• First-hand experience of the installation, working and regular upkeep of AMBER biomolecular simulation package in a high-performance computing infrastructure is a primary requirement for the position.
• Skills in the area of computer-aided drug discovery such as virtual database screening, structural bioinformatics, pharmacophore modeling, small molecule, and protein/peptide docking.·       Knowledge of shell scripting and other programming languages.
• The candidate should have a strong publication track-record in peer-reviewed scientific journals with a proven ability to work independently.
• The candidate should be self-motivated, possess good communication skills, and an established aptitude to interact effectively and work productively in a highly interdisciplinary research group. 

• Particular attention will be considered for candidates with research expertise in the design and development of candidate molecules for anti-cancer therapeutics through rational structure-based drug design.
• Experience of working/collaborating with industry related research work.
• Candidate with teaching experience will be preferred.
• Experience with mentoring/supervising students will be positive.

Great emphasis will be placed on personal competency.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

The application must be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.