Research Specialist in Metadegradomics

Updated: 2 months ago

Do you want to contribute to top quality medical research?

Are you interested in the crosstalk between ribosome dynamics and mRNA decay? Would you like to contribute to the development of cutting-edge genome-wide technologies? Come and join us at SciLifeLab.

The Department of Microbiology, Tumor and Cell Biology conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 400 active employees, including PhD students, postdoctoral researchers and professors.

The laboratory of Vicente Pelechano is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus in Solna. SciLifeLab is equiped with state-of-the-art instrumentation and core facilities, and is home to one of the largest sequencing cluster in Europe. SciLifeLab Stockholm is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH) and Stockholm University, and hosts research groups with diverse backgrounds and expertise, including basic biology, drug discovery, genomics, bioengineering, and translational medicine.


The Research group

Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.


Your mission

The available position as research specialist concerns developing and applying novel experimental approaches to study gene expression and RNA metabolism across multiple organisms. The candidate will focus on the RNA biology and determinants of mRNA stability in multiple settings. This will include the study of the crosstalk between translation regulation and mRNA decay using novel developed genomic tools. The candidate will perform original research in genomics and molecular biology, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate will use multiple model organism, from bacteria to human.

The selected applicant will be responsible for developing and implementing experimental approaches to investigate the regulatory crosstalk between ribosome dynamics, mRNA degradation and the response to drugs and other environmental perturbations. The successful candidate will take a strong lead in the experimental design, and collaborate with other team members. A successful candidate is expected to assist the group leader in issues such as written reporting of laboratory activities, research grant applications and long-term planning of laboratory development.

The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.


Your profile

The successful applicant should have experience interpreting biological data and experimentally testing their hypothesis. Previous experience in RNA biology with a focus on mRNA decay and ribosome dynamics is essential. The successful applicant should have excellent skills in experimental techniques such as NGS library preparation, polyribosome fractionation and yeast genetics. Experience in microbiology and anaerobic bacteria culturing will be highly considered. A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential. Preferred experience also includes familiarity with bioinformatics and NGS data analysis. Good interpersonal skills and ability to work in teams is essential.


What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna


Application

Welcome to apply at the latest 2021-07-08

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.


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