Research Specialist in Heart Regeneration

The central scientific interest of the Eroglu laboratory, is to understand mechanisms of heart regeneration at the molecular and cellular level, with the ultimate goal of applying the regenerative principles, logic, pathways, technology, and model systems to enhance the regenerative capacity of the human heart. We use several different approaches to study heart regeneration, including cryoinjury model in salamanders and in vitro stem cell differentiation systems.

We are seeking a highly motivated and enthusiastic research specialist with a strong background in the heart regeneration field. The research project will focus on characterizing the role of tight junctions in epicardial progenitor activation and differentiation and establish live imaging methodologies and transgenic lines to perform force measurement.

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated substantial research expertise as well as have documented scientific productivity after defending their doctoral dissertation.

In addition, it is required to have:

• A strong background in molecular and cellular biology.
• Knowledge regarding cardiac tissue regeneration and heart disease is demonstrated by work performed in regenerative species such as salamanders and zebrafish.
• Experience in confocal and in vivo microscopy, preferentially with hands-on experience in live imaging of heart tissue and imaging-based assessment of heart function and cardiac tissue regeneration.
• Experience in working with cell culture including stem cell differentiation, cell co-cultures and 3D cell culture systems using biopolymers, as well as generation of cardiac organoids.
• Practical laboratory experience in the following areas: gene editing, molecular cloning, DNA/RNA purification, genotyping, qPCR, recombinant protein expression and isolation, histology and immunohistology.
• Excellent knowledge of English, both spoken and written. 

It is particularly meritorious that the applicant has shown:

• Demonstrated ability to generate and validate transgenic and mutant lines.
• Experience in performing cardiac surgical procedure in salamanders.
• Training and supervising trainees and students.
• Capacity to write competitive research grant applications and obtain independent research funding.

As a person, we would like you to be energetic and passionate to fit in and actively contribute to our team. In this recruitment, we place great importance on personal qualities.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

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We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

The application must be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.