Research specialist in experimental lung immunology

We are recruiting a research specialist to join our international research group conducting translational immunological studies to lung disease pathogenesis. This position is focused on the role of antigen-specific leukocytes (T cells and B cells) in the immunopathology of sarcoidosis.

As a research specialist you will develop and work on new and ongoing projects and experimental and analytical methods in the research group. In addition to generation of experimental data, the work also includes literature review, statistical analysis, data analysis and scientific writing.

The studies primarily use patient samples from blood and tissue, in particular samples from the airways. Handling and processing of patient samples in biosafety level 2 are central in this position, as well as coordination between the clinic and the research laboratory. Patient samples are analysed using flow cytometry, RNA sequencing and an array of immunological and molecular methods. In addition, cells from patient samples are FACS sorted and used for functional in vitro assays including functional B cell assays, ELISA and RNA sequencing.

The successful candidate should have documented experience and skills in experimental immunological work with patient blood and tissue samples, preferentially respiratory samples. The candidate should have well established knowledge in immunology and experimental methods related to these fields. Documented skills in patient sample processing, human primary cell culture, FACS and cell sorting are required. Experience with experimental B cell immunology is a merit. The candidate should be able to communicate well in English and be able to work independently as well as with others

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

It is particularly meritorious that the applicant has shown

• Documented experience with ELISA including establishing in house ELISA methods

• Documented experience on processing and culture of cells from human blood and tissues

• Documented experience with flow cytometry

• Documented experience with experimental immunology including B cell analyses

• Documented experience with RNA sequencing data generation and analysis

• Good communication and organizational skills

• Excellent skills in spoken and written English

• Capacity to work independently as well as in a team

It is meritorious that the applicant has shown

• Experience in methods of molecular biology

• Experience in supervision

• Experience in writing grant applications

• Experience in coordinating work with clinical collaborators and the research laboratory

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within theresearchgroupof Johan Grunewald, at the Division of Lungmedicine. https://ki.se/meds/lungmedicin

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest february 5th.

The application must be submitted through the Varbi recruitment system.