Research engineer to CBCS facility Compound Center

Chemical Biology Consortium Sweden (CBCS) KI node is currently seeking a versatile organic chemist with competence in analytical chemistry who will help CBCS in its mission to provide the entire consortium and its users with small molecules from our compound collection. At CBCS you will work closely in a team of biologists and medicinal chemists within a vibrant research community, to enable chemical biology and drug discovery innovations.

CBCS is a Swedish Research Council funded infrastructure of national interest with nodes at Karolinska Institutet, Umeå, Lund, Uppsala, Linköping and Gothenburg Universities. CBCS (www.CBCS.se) has been in operation since 2010 and is an infrastructure for chemical biology at Science for Life Laboratory (www.scilifelab.se). CBCS offers services for the identification of chemical tools (bioactive small molecules) for all fields of life sciences. The infrastructure offers collaborative service and guidance within assay development, small-molecule screening and hit to chemical probe optimization. Additional service offerings in small-molecule profiling, including Cell Painting, and screening in primary and complex disease models.

The facility comprises CBCS Compound Center whose assignment is to serve the Swedish research community with distributing screening libraries on assay plates while preserving the quality of our collection. We also support precision medicine through functional testing in patient-near cells by endorse profiling of small molecules and disease models at single cell level and in patient-derived cells. The collection consists of over 350 000 chemical compounds and instrumentation includes a fully automated storage system; Liconic Kiwi ST-30 combined with a Bravo liquid dispensing system (Agilent) together with an acoustic liquid dispensing platform (Echo 550 & workstation) The collection is stored under environmentally controlled conditions and regular quality campaigns are performed to maintain the integrity of the collection.

We seek one individual within the fields of compound management and chemistry to join our team. The successful candidate will be part of an automation team and play a key role providing technical expertise in the creation of a national sample operation and expansion of capabilities to meet future needs of research. In this position you will work in a dynamic environment whilst supplying essential service to research projects across the academic world in Sweden. The work is highly collaborative, and you will join a team with collective responsibility for the overall delivery. The group has a strong emphasis on continuous improvement which you will contribute to in the form of individual and group projects.

Responsibility includes:

• Support the team around storage, retrieval, replication, and distribution of small molecule libraries to academic research groups.
• Provide support of research activities, anticipate, identify, and resolve data and application issues, and implement new concepts to help manage local sample collection and impact strategic direction and priorities for research.
• Establish and maintain a productive network of relationships within SciLifeLab and Karolinska Institutet and their collaborative partners to understand customer needs for sample plates and work to deliver the capabilities and capacities needed.
• Contribute to and participate in the implementations to improve and update the informatics system that is integrated with the automated systems.
• Buildup and development of an automated quality control/assurance process for our stored 10mM DMSO solutions, screening libraries and collection of solids. Involving performance of regular campaigns of routine sample analysis and evaluation of data obtained from HPLC-MS.

To be eligible for an employment as research engineer the applicant MSc in Bioscience or Chemistry or BSc with equivalent experience.

We believe that you are comfortable working at a fast pace with a goal orientated and

team focused attitude. Possessing excellent communication skills with a dedicated and service minded approach is key. It is very important that you fully understand the drug discovery process and have technical proficiency along with necessary skills in chemistry, process engineering, QA and QC, automation solution development, instrument services, data management and method development for HPLC-MS, both chromatographic and ability to process automated evaluations of the result.

To be considered for this position, you should have

• Demonstrated history of working in the drug discovery process with a strong scientific knowledge foundation.
• Minimum of 5 years experience of laboratory work handling chemical samples
• Minimum of 2 years experience in utilizing sample management hardware systems such as automated storage freezers and acoustic dispensing technologies. Experience of utilizing software’s such as Beckman Echo Tempo, Echo Reformat, Echo Cherrypick, Agilent Bravo VWorks, Agilent OpenLab CDS chemstation edition, Molsoft Scarab, CBCS Cello and CBCS ChemReg will be highly valued.
• Experience using various IT systems and strong personal computer software knowledge, general and extended such as knowledge of SQL is valued. Proficiency skills and rapid handling in excel is required together with ability to discover deviation in a large set of data.
• Experience in performing quality assurance/quality control of a large number of compounds using Agilent 1260 Infinity II HPLC UV/MS with following evaluation of data including automated processing of result.

We expect you to be a positive, flexible person working in a clean and precise way. Interpersonal skills will be highly valued.

The successful candidate must have a "staff scientist" mindset, be service-minded, and be dedicated to high-quality and reproducible data production. You should possess very good interpersonal and cooperation skills, enjoy collaborative science, be flexible, and be capable of working independently in a structured and efficient way. Excellent communication skills in written and spoken English are essential, as well as documentation skills, and experience with electronic lab notebooks is merited.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: SciLifeLab, Solna

More information about CBCS and SciLifeLab is found at https://www.cbcs.se/ and https://www.scilifelab.se/

Welcome to apply at the latest February 5th 2024.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

Permanent position is initiated by a six months trial period.