Do you want to contribute to top quality medical research?
We are recruiting a research assistant to provide support to the Hellström-Lindberg group . The group research focus is on cellular and molecular pathways underlying aberrant stem cell function and ineffective erythropoiesis in myelodysplastic syndromes (MDS). Recent studies from our group on this subject encompass Elvarsdottir, et al., Leukemia 2020, Shiozawa, et al., Blood 2017, Mortera Blanco, et al., Blood 2017, Dimitriou, et al., Oncotarget 2016, Conte, et al., Br J Haematology 2015; Malcovati, et al, Blood 2015, Woll, et al., Cancer Cell 2014, Nikpour, et al. Leukemia 2013. We are exploring MDS pathogenesis along two lines; to understand the competitive advantage of SF3B1 mutated stem cells in the human niche, and to outline the mechanisms behind terminal erythroid failure. This is studied in primary patient samples from our MDS biobank, utilizing diverse technologies such as advanced flow cytometry, high-throughput RNA sequencing including single cell analysis, and various in vitro and in vivo stem cell assays.
The position will be for 6 months and be placed at HERM . The research group and the department offer an engaging and international research environment where a research assistant will have the opportunity to contribute to high-quality research and capacity building at the international top level.
Myelodysplastic syndromes (MDS) comprise a broad spectrum of hematological malignancies affecting the HSC compartment and causing myeloid cytopenias. One particular subtype, MDS with ring sideroblasts (MDS-RS), is largely caused by de novo mutations in the gene SF3B1 and other splice factors and is characterized by severe anemia with limited treatment options.
As a research assistant you will work in a multidisciplinary team and provide support in characterizing the cellular and molecular mechanisms underlying MDS-RS towards the identification of novel targetable pathways to minimize the disease’s impact. You will employ a combination of flow cytometry (to isolate distinct hematopoietic stem and progenitor cells), advanced cell and molecular biology techniques, high throughput characterization approaches, general data analysis and bioinformatics.
Applicants should have at least a master’s degree in medicine, molecular biology or immunology. Candidates with a combined background covering medicine, biology, math and programming are highly encouraged to apply. Bioinformatic experience using R will be looked upon favorably. Similarly, previous experience with single cell RNA sequencing, flow cytometry for analysis of primary hematopoietic cells, and animal studies will be looked upon positively. Applicant should be fluent in English (written and spoken). Emphasis will be placed on personal suitability.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.
Choose to work at KI – Ten reasons why
Welcome to apply at the latest 2022-10-06
The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.
Want to make a difference? Join us and contribute to better health for all
Postdoctoral Researcher To Target Mechanisms Driving Cancer Cell…, Karolinska Institutet (KI), Sweden, 1 day ago
Do you want to contribute to top quality medical research? A postdoctoral position within the exciting field of gene regulatory networks in cancer is immediately available in the laboratory of Pro...
Postdoc/Research Associate In Translation Regulation Of Hematopoiesis, Hebrew University of Jerusalem (HUJI), Israel, 3 days ago
We are recruiting experienced and motivated postdocs or research associates for full time positions, funded by the European Research Council (ERC). We are seeking enthusiastic scientists with an i...
Postdoc In Subcellular Resolved Spatial Transcriptomics, University of Southern Denmark (SDU), Denmark, 6 days ago
At the Department of Biochemistry and Molecular Biology, SDU we are looking for a highly motivated researcher for a two-year position, who will work with state-of-the-art subcellular-resolved spat...
Postdoctoral Researcher In Developmental Cardiovascular Medicine And Stem Cell Biology, Karolinska Institutet, Sweden, 14 days ago
Do you want to contribute to top quality medical research? The Ken Chien group belongs to the Department of Cell and Molecular Biology (CMB) at the Karolinska Institute in Stockholm, one of the wo...
Researcher In Physical Chemistry (Pa2022/3710) , University of Lund, Sweden, 1 day ago
Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has around 46 000 students and more than 8 000 staff based in Lund, Helsingborg ...
Research Fellow (Biological Sciences), NATIONAL UNIVERSITY OF SINGAPORE, United Kingdom, 11 days ago
Job Description Post-Doctoral Fellow Positions in Cultured Seafood Meat My Laboratory in National University of Singapore (Department of Biological Sciences) is seeking two highly-motivated Post-D...