Research Assistant position in stem cells and erythropoiesis in MDS

We are recruiting a research assistant to provide support to the Hellström-Lindberg group . The group research focus is on cellular and molecular pathways underlying aberrant stem cell function and ineffective erythropoiesis in myelodysplastic syndromes (MDS). Recent studies from our group on this subject encompass Elvarsdottir, et al., Leukemia 2020, Shiozawa, et al., Blood 2017, Mortera Blanco, et al., Blood 2017, Dimitriou, et al., Oncotarget 2016, Conte, et al., Br J Haematology 2015; Malcovati, et al, Blood 2015, Woll, et al., Cancer Cell 2014, Nikpour, et al. Leukemia 2013. We are exploring MDS pathogenesis along two lines; to understand the competitive advantage of SF3B1 mutated stem cells in the human niche, and to outline the mechanisms behind terminal erythroid failure. This is studied in primary patient samples from our MDS biobank, utilizing diverse technologies such as advanced flow cytometry, high-throughput RNA sequencing including single cell analysis, and various in vitro and in vivo stem cell assays.

The position will be for 6 months and be placed at HERM . The research group and the department offer an engaging and international research environment where a research assistant will have the opportunity to contribute to high-quality research and capacity building at the international top level.

Myelodysplastic syndromes (MDS) comprise a broad spectrum of hematological malignancies affecting the HSC compartment and causing myeloid cytopenias. One particular subtype, MDS with ring sideroblasts (MDS-RS), is largely caused by de novo mutations in the gene SF3B1 and other splice factors and is characterized by severe anemia with limited treatment options.

As a research assistant you will work in a multidisciplinary team and provide support in characterizing the cellular and molecular mechanisms underlying MDS-RS towards the identification of novel targetable pathways to minimize the disease’s impact. You will employ a combination of flow cytometry (to isolate distinct hematopoietic stem and progenitor cells), advanced cell and molecular biology techniques, high throughput characterization approaches, general data analysis and bioinformatics.

Applicants should have at least a master’s degree in medicine, molecular biology or immunology. Candidates with a combined background covering medicine, biology, math and programming are highly encouraged to apply. Bioinformatic experience using R will be looked upon favorably. Similarly, previous experience with single cell RNA sequencing, flow cytometry for analysis of primary hematopoietic cells, and animal studies will be looked upon positively. Applicant should be fluent in English (written and spoken). Emphasis will be placed on personal suitability.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Flemingsberg

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Welcome to apply at the latest 2022-10-06

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.