Postdoctoral Researcher in Translational Epigenetics and Women’s Cancer

Updated: 22 days ago

Do you want to contribute to top quality medical research?

Our team at the WHO collaborating center at the Department of Women’s and Children’s Health, Division of Neonatology, Obstetrics and Gynecology is interested in the role of selective progesterone receptor modulators (SPRMs) in women’s health. We now offer a post doc position to study the fundamental biology of these agents. DO you want to join our interdisciplinary team and work with us on our common vision which is to make women’s cancers a disease of the past?


Your mission

Within the context of research projects including the European Research Council (ERC) BRCA-ERC programme (PI: Prof Martin Widschwendter), we will study the role of the progesterone receptor antagonists in women with a germline BRCA1 or BRCA2 mutation on breast and ovarian cancer prevention without concurrently increasing the risk for endometrial cancer. We will utilise clinical samples, primary cell organoid models, epigenetic (i.e., DNA methylation and chromatin structure), genetic (i.e., somatic mutations), and single cell technologies to assess the effects of progesterone and progesterone receptor antagonists.


Your profile

We are looking for an enthusiastic postdoctoral candidate with experience in organoid cell culture and, ideally, basic experience in single cell sequencing to join our research lab located in BioClinicum.

Essential:

  • Cell culture (specifically experience with organoid primary cell culture).
  • Conventional molecular techniques including PCR and Western Blot.
  • Basics of single cell sequencing.
  • Team player and willingness to interact with clinicians and other relevant team members.

Desired:

  • Culture of primary normal breast and/or Fallopian Tube and/or endometrial cells.
  • DNA methylation analyses.
  • Duplex sequencing.
  • Live cell imaging technologies.
  • Experience in single cell sequencing – both RNA and ATAC – of heterogenous tissue.
  • Basic bioinformatic skills.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.


What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.


Location:
Solna

About the Department of Women's and Children's Health
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Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest May 16th 2021.

The application is to be submitted through the Varbi recruitment system.


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