Systems microscopy of cancer cell migration – an SSF-supported interdisciplinary network project
Systems microscopy of cancer cell migration is a five year interdisciplinary network project supported by the Swedish Strategic Research Foundation (SSF) program on systems biology. This project aims at elucidating how cellular signaling and applied forces are coordinated to control cancer cell migration and involves technology development, cell biology, advanced microscopy, image analysis, bioinformatics, multivariate statistics and mathematical modelling. This collaborative project is coordinated by Karolinska Institutet and also includes Uppsala University and Lund University, as well as the biotech companies Sprint Bioscience and Olink Bioscience.
Department of Biosciences and Nutrition at Karolinska Institutet
The Department of Biosciences and Nutrition performs research and education in areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. The department offers an international study and working environment, including around 300 scientists, students, administrative and technical personnel.
Description of project and work
This postdoc project will be conducted in the research group of professor Staffan Strömblad (http://ki.se/en/bionut/cell-biology-of-cancer-staffan-stromblad ). Our group is interested in cancer biology, with particular emphasis on cell migration, cell-matrix interactions and cellular signaling. The project will focus on analyzing how cell migration plasticity is controlled by the underlying cellular machinery. The successful applicant will participate in an interdisciplinary network project supported by the Swedish Strategic Research Foundation described above. Within this project, this postdoc will lead a study on plasticity in cancer cell migration that will be conducted in close collaboration with Uppsala University and involve live cell microscopy, image analysis, single cell expression profiling, bioinformatics, mathematical statistics and modelling. This postdoc project provides opportunities for growth and development as an independent researcher, as there will be possibilities for initiating new research directions. Selected recent publications: Shaftqat-Abbasi et al E-life 2016, doi: 10.7554/eLife.11384; Hernandez-Varas et al. Nat Commun 2015, doi: 10.1038/ncomms8524.
You will be supervised by prof. Staffan Strömblad and work together with postdocs and senior scientists both within the group and within the SSF-supported network that will start in September 2017 and run for five years.
The applicant should hold a PhD in a related area and should have significant experience in the vast majority of the following areas: Cell biology; expression profiling; live cell confocal microscopy; image analysis; bioinformatics; multivariate statistics and mathematical modelling. Programming experience is required; please specify mastered coding languages in the application. The applicant should be able to conduct a project independently and critically. Applicants must possess excellent communication skills and be able to interact and work efficiently in a team. Excellent spoken and written English is required.
A person is eligible for this position as Postdoctoral Researcher if he or she has obtained a PhD no later than 2014.
Starting date and duration
The position is immediately available. The duration will be for two years with an option of prolongation for another two years.
An employment application must contain the following documents in English:
The application is to be submitted through the MyNetwork recruitment system.
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