Postdoctoral researcher in mitochondrial structural cell biology

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

The Hällberg laboratory is offering a stimulating and interactive international environment. We are part of the Department of Cell and Molecular Biology at the Karolinska Institutet in Stockholm, Sweden, one of the world ́s leading medical universities. The lab is located in the recently opened Biomedicum, a state- of-the-art research building.

We are seeking a highly motivated and enthusiastic postdoctoral fellow interested in studying the structural cell biology of mitochondrial genome separation and segregation. The project is part of a multi-disciplinary collaboration financed by the Knut and Alice Wallenberg Foundation.

The project aims to structurally characterize the DNA intermediates formed during the separation of newly replicated mtDNA and players involved in this separation process. Main techniques involved are electron microscopy (cryo-EM), cell biology and biochemistry. Main techniques involved are electron microscopy (cryo- EM), macromolecular crystallography and biochemistry. We have ample access to Karolinska Institutet’s 3D-EM facility that currently features a Krios G3i with a Bioquantum K3, an Aquilos2 cryo-FIB-SEM, a Leica SP8 cryo-confocal, a Talos 120C G2 and a range of sample-preparation equipment.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

We are looking for highly motivated, independent and driven candidates. The successful applicant will have extensive experience with structural determination of protein complexes in general and mitochondrial gene expression complexes in particular. A documented ability and more than 1-year experience in independent operation of a 300 kV Krios microscope and cryo-FIB-SEM is required for this position. Furthermore, a documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and a summary of skills and experience
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Applications will be screened continuously, and we may start the interview process before the last day of application.