The Division of Molecular Metabolism (read more about it here: http://ki.se/en/mbb/research-divisionof-molecular-metabolism ), Department of Medical Biochemistry and Biophysics (http://ki.se/en/mbb ), is located at the Retzius laboratories at Solna campus of Karolinska Institutet. The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease. The current research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mtDNA expression and other aspects of mitochondrial metabolism. The overall aim of the Division of Molecular Metabolism is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatments.
The Division of Molecular Metabolism offers an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The newly founded Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KI laboratory) is also integrated into our laboratory. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory (https://www.scilifelab.se ).
We are currently looking for a highly motivated postdoctoral researcher to join the research group of Joanna Rorbach.
Mitochondria are sub-cellular organelles essential for eukaryotic cell function, and their dysfunction has been implicated in a variety of hereditary diseases, ageing, cancer and immunity. The correct expression of mtDNA (our second genome) is essential for normal mitochondrial function. The objective of our research is to better understand the post-transcriptional regulatory networks controlling gene expression in mitochondria; as a means to identify the pathways and factors important to human mitochondrial diseases and improve our understanding of the fundamental mechanisms of eukaryotic cell function. More specifically, we focus on: i) RNA-protein interactions in mitochondria; ii) mitochondrial ribosome biogenesis; iii) biochemical and structural characterization of the mitochondrial translation machinery. We employ multidisciplinary approaches and diverse model systems to address these questions, including high-throughput gene targeting, mitoribosome profiling, and proteomic and cryo-EM methods
Successful applicant requirements
Enthusiastic and motivated applicants should have a strong background in biochemistry and molecular biology. Furthermore, we expect applicants to have previous experience of mammalian cell culture and various molecular biology techniques. Specific experience in mitochondrial or structural biology is an advantage given the nature of the research, but is not a requirement.
The successful applicant should be knowledgeable of biological advancements, demonstrate a promising publication record, and have a rigorous scientific approach.
Good documentation skills as well as proficiency in both spoken and written English are required.
The successful candidates should be willing to work in a highly collaborative environment and to pursue his/her own independent research. Our research group is located in the world-leading Karolinska Institutet and works with groups within Sweden and abroad.
A person is eligible for a position as a Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.
An employment application must contain the following documents in English or Swedish:
The application is to be submitted through the MyNetwork recruitment system.
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