Postdoctoral Researcher in human NK cell biology

We are looking for a highly motivated and skilled postdoctoral researcher to join the Michaëlsson group in our efforts to decipher the functional regulation of Natural Killer (NK) cells in lung tumors. The overall research interest of our group is human innate lymphocytes, in particular NK cells, in health and disease. Our studies encompass basic and translational immunology of innate lymphocytes in tissues, from fetal development to adulthood, and typically are performed in collaboration with clinicians at the Karolinska University Hospital. The current position focuses on understanding the biology of NK cells in human lung tumors.

The successful candidate will study NK cells in human lung and lung tumors using combinations of molecular-, cell biological and immunological techniques, including advanced multicolor flow cytometry, single cell RNA sequencing and in vitro assays. The projects aims at furthering our understanding of NK cells in the lung and lung tumor, in particular to explore ways to potentiate these cells for eradication of tumor cells. Parts of the work will be performed in close collaboration with other members of the group, but the candidate is also strongly encouraged to develop independent projects.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Applicants should have a strong background in human immunology with expertise in the biology of human innate lymphocytes and/or tissue-resident lymphocytes. As the project to a large degree is based on flow cytometry analysis, proven competence in advanced multicolor flow cytometry analysis and sorting is required. Experience of single cell RNA sequencing and analysis as well as experience in in vitro cytotoxicity assays using innate lymphocytes are meriting. Excellent communication and writing skills in English are mandatory as the successful candidate will be working closely with other members of the group and our collaborators. The postdoctoral fellow is expected to plan, execute, and analyze experiments in an independent manner, as well as in collaboration with other researchers at CIM, and to contribute scientifically to CIM and the Michaëlsson group.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Within the Michaëlsson group, currently consisting of the group leader, one senior researcher/Team leader, one post-doc and two PhD students, we offer a highly collaborative environment with strong expertise in human tissue-immunology, cutting-edge multiparameter flow cytometry, single cell RNA sequencing, and a common enthusiasm for human NK cell research. The environment at CIM encompasses 16 research groups within the fields of immunology, infection, cancer and autoimmune diseases, operating under the same roof with shared infrastructure, close collaborations, joint seminar series and a great social environment.

Location: Flemingsberg

Read more about the department of Medicine, Huddinge

Read more about the Michaelsson group

An employment application must contain the following documents in English:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)
• A letter of motivation describing why the applicant is applying and why they are suitable for the position.

Welcome to apply at the latest 2022-11-15

The application is to be submitted through the Varbi recruitment system.