Postdoctoral Researcher in human hematopoietic stem cell niche

Join us!

A position is available within the laboratory for Cell, Tissue and Organ engineering (www.bourginelab.com ) led by Paul Bourgine. The group is specialized in the bioengineering of human mini-bones recapitulating in vivo the human bone marrow niche organization and function.

Curious? Check our latest work!

- https://www.science.org/doi/10.1126/scitranslmed.abm6391

- https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30044-7

Your mission

We are looking for a candidate with a high and healthy ambition to discover! The successful candidate will hold a postdoctoral position for two to four years (renewable) funded by an ERC Starting grant. The project will consist in harnessing the human mini-bone technology. The approach will be exploited under various axes:

(i) study the engraftment of leukemic patient materials and the corresponding impact of the human niche in disease progression

(ii) validate the human mini-bone as superior drug-testing platform in AML/MDS contexts

Your profile

Absolute requirements: you possess a PhD degree in biology or equivalent and a strong background on the hematopoietic system biology. You have solid experience in flow cytometry, cell culture and animal experimentation. You have a collaborative spirit and good command of spoken and written English.

Preferred requirements: past-experience in Leukemia or on the study of the bone marrow niche is a strong asset, particularly in Acute Myeloid Leukemia context. Skills or interest in confocal microscopy, drug screening, spatial/scRNA transcriptomic is a plus.

What we can offer you

You will be most welcome in a young, friendly and dynamic environment! The laboratory will offer you robust training in bioengineering, stem cell biology, hematopoiesis and cancer research. The lab is developing and exploiting state-of-the-art technologies including 3D printed bioreactor systems, lentiviral barcoding coupled with single cell omics, quantitative confocal microscopy, primary tumor models (leukemia and solid tumors), microtomography, animals, CRISPR/Cas9, etc. We have a high collaborative spirit providing an excellent environment to grow and learn new techniques. Opportunities to join or create new national/international collaborations will be proposed. A competitive starting salary will be set based on the candidate experience.

The institute

You will be part of the Wallenberg Center in Molecular Medicine and the Stem Cell Center within Lund University (Sweden). You will benefit from state-of-the-art services/equipment, the institute being a modern centre with all technologies/facilities available on site. The university founded in 1666 is the first Swedish University and is repeatedly ranked among the worlds top universities. With a direct connection to Copenhagen International airport (30min), Lund is an accessible city and a European hub for research.

Application / Contact

Candidates should send a CV, a short summary of research experience, and contact information for referees to: [email protected]