Postdoctoral Researcher in bone metastatic cancer biology

The division of Pediatric Oncology and Pediatric Surgery is a constellation of interdisciplinary research groups that are conducting laboratory, clinical, survivorship and healthcare research with the common goal to improve the survival, quality of life, care and treatment of children and adolescents with cancer or hematological diseases. Education is also performed at many academic levels, and we arrange courses and national and international meetings.

Baryawno research group
The Translational embryonal neural tumor research laboratory is located at Bioclinicum in Stockholm and affiliated with the Childhood Cancer Research Unit, Dept of Women’s and Children’s health, Karolinska Institutet. The Baryawno laboratory consists of 3 Ph.D. students and is part of the group constellation of professor Per Kogner, associate professor John Inge Johnsen and associate professor Malin Wickström. The group consists of a total of 12 Ph.D. students and postdoctoral fellows. The focus of our research is to increase our biological understanding of the embryonal tumor neuroblastoma, to develop new therapies leading to better survival, less side effects and increased quality of life. We are applying basic, translational and clinical approaches in our research including, single cell technologies, bioinformatics, immunology and molecular biology as well as functional analysis and development of preclinical animal- and in vitro-models.  

The current project will be focused on creating a novel animal model of bone metastatic neuroblastoma both from murine and human cells. It will further use imaging techniques such as live PET imaging in mice to characterize the experimental model that has been generated, but also immunohistochemistry and singel-cell RNA-seq. The aim is to investigate the cellular and molecular landscape of neuroblastoma bone metastases at the single cell level and mechanisms of communication between cells within the tumor microenvironment in order to search for resistance mechanisms and novel therapy options. The postdoctoral candidate will be mentored by Dr Baryawno on the proposed project. More information on the work from the lab can be found in recent publications (Baryawno et al., Cell 2019; Kfoury, Baryawno et al., Cancer Cell 2021; Verhoeven et al., Cell Reports Medicine 2022; Alchahin et al., Nature Communications et al., 2022, Olsen et al., JCI Insights 2022).

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The successful candidate should have a PhD in life sciences obtained no earlier than 2022. Experiences with preclinical animal cancer models and imaging methods such as live PET imaging for mice, and skills in various injection techniques in mice are essential. The ability to work with people of different backgrounds and contribute to a project team is important. Applicants must be able to work independently and have good communication skills in English.  

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

https://ki.se/en/kbh/translational-research-of-childhood-neural-tumours
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Application process
An employment application must contain the following documents in English or Swedish:

Assessment criteria
A selection will be made among qualified applicants based on the following criteria:

• Documented subject knowledge of relevance to the area of research
• Expressed interest in the proposed project
• Other documented experience relevant to the subject and planned project

The qualifications of the applicants will be evaluated on an overall basis.

The application is to be submitted through the Varbi recruitment system.