Postdoctoral Researcher for beta-cell regeneration in zebrafish

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and metabolism. CMB is located in Biomedicum, a new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum houses approximately 1,200 researchers and other personnel and allow expensive equipment to be shared and used more effectively.

Description of the research group

The main interest in the lab of Olov Andersson is to study how small molecules and cellular mechanisms can promote regeneration of insulin-producing beta-cells and improve metabolic control, as future curative approaches for diabetes. In an ERC-funded lab the successful applicant will use genetics and single-cell transcriptomics in zebrafish to identify compounds, genes and signalling pathways that can promote β-cell regeneration.

Visit the lab’s website:

https://ki.se/en/cmb/olov-anderssons-group

For examples of how the research can be conducted, please see:


Karampelias et al., Nature Chemical Biology:

https://www.nature.com/articles/s41589-022-01047-x

Charbord et al., Nature Metabolism:

https://www.nature.com/articles/s42255-021-00391-x?proof=t

Mi et al., Life Science Alliance:

https://www.life-science-alliance.org/content/6/5/e202301944

The present project will span from developmental biology to genetics in zebrafish, as well as translational transcriptomics. The studies will include assessing beta-cell neogenesis, proliferation and transdifferentiation, and how such cellular changes affect glycemia.

The zebrafish are amenable to efficient transgenesis and high-resolution imaging. We will make use of these properties to generate transgenic, knock-in and mutant zebrafish for single-cell analysis of phenotypes and lineage tracing. The successful applicant will have a strong background in cell and molecular biology or biochemistry, and keen interest in using model organisms to study beta-cell regeneration and metabolism.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for independent and driven candidates who have at least one first-name publication in a peer-reviewed journal. A documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English.

The successful applicants should have experience in several of the following techniques/models:

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Stockholm

Video about a Karolinska Institutet, how we work towards "a better health for all''

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.