Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 81 PhD students, 77 postdoctoral researchers and 32 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations.
The research group of Dr Claudia Kutter seeks applications for a postdoctoral position in the field of RNA biology and genomics. The Kutter lab explores the molecular mechanism by which noncoding RNAs (i.e. long noncoding, transfer and small RNA) regulate genes and genome structure in somatic tissue and in the germline in mammals (Rudolph et al, PLoS Genetics, 2016; Schmitt et al, Genome Research, 2014; Kutter et al, PLoS Genetics, 2012; Kutter et al, Nature Genetics 2011). The research program for this position focuses on the regulation of noncoding RNAs during cell differentiation and disease progression, with a particular interest in the involvement of RNA binding proteins during transcript processing and how they synergize with other cofactors in mammalian systems by using diverse cell lines, mouse and human tissues as model system. The roles of noncoding RNAs are interrogated genome- and transcriptome-wide by employing a combination of next generation sequencing technologies and high-throughput genetic screening approaches, developing computational methods, along with additional biochemical, molecular and cell biological methods. The group uses an integrative and collaborative approach, and works closely with experimental and computational groups at the MTC, Science for Life Laboratory (SciLifeLab), and other local and international research groups. Additional professional training is available through summer schools and workshops.
The laboratory is located in the newly established SciLifeLab on the Karolinska Institute campus in Stockholm. The SciLifeLab offers an attractive research environment, provides state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. The SciLifeLab is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH), and Stockholm University. It hosts research groups with diverse backgrounds and expertise, creating a unique interface between basic biology, genomics, bioengineering, drug discovery, and translational medicine.
The successful applicant will develop and integrate novel transcriptome- and genome-wide computational methods (based on RNA- and ChIP-sequencing data) to study the processing and regulation of noncoding RNAs in mammalian cell lines. The work implies original research in computational biology, designing computational methods and implementing analytical pipelines to infer underlying molecular mechanisms. The post holder will take a strong lead in the project design and management, data generation and interpretation, and collaborate with other team members. The ideal candidate is expected to report the scientific results by writing scientific papers, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must.
A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.
A strong background in genomics, computational biology, and/or statistics as well as experience in high-throughput biological data analysis, extensive scripting and programming knowledge, data visualization is required. Prior knowledge in eukaryotic RNA biology, gene regulation, and transcriptome-wide studies is an asset. The ideal candidate should be collaborative, scientifically adventurous, curiosity-driven, and should bring independent and original ideas into the project. Any previous records of independent research as well as productive interactions within a multi-disciplinary team environment (e.g. first- and/or co-author publications in high profile journals) are advantageous. All applicants should have good communication skills and be proficient in spoken and written English.
For more information on the work of the laboratory, please visit https://www.scilifelab.se/researchers/claudia-kutter/ or http://ki.se/en/mtc/claudia-kutter-group
To make informal enquiries about the post, please contact Dr Claudia Kutter at firstname.lastname@example.org
An employment application must contain the following documents in English or Swedish:
The application is to be submitted through the MyNetwork recruitment system.
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