Postdoctoral position in hematologic genetics and epigenetics

Published: 2023-01-11

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.

The Department of Medical Sciences is a large clinical institution with more than 250 employees and over 900 additional coworkers connected via the Uppsala University Hospital. The Department of Medical Sciences has a broad research profile with strong research groups in a number of different areas. The research carried out at the department is performed in close connection with the clinical activities at the Uppsala University Hospital, which includes both basic studies on the causes of a variety of illnesses and the development and evaluation of improved diagnostics and new treatment methods. More information about the Department of Medical Sciences can be found at www.medsci.uu.se

Duties
We are looking for a skillful, ambitious and highly motivated researcher/post-doc to work within Sören Lehmann’s hematological research group in a project on epigenetic studies of leukemia. The aim of the study is to define leukemia specific molecular and functional changes in leukemia cells with a focus on epigenetic mechanisms. This project will improve our understanding on why normal blood cells develop into leukemia cells and how epigenetic changes in the cells can be used as biomarkers and/or as target structures for new and more effective treatments for leukemia. The project includes analyzes of leukemia cells using whole genome sequencing by ChIP-seq, ATAC-Seq, Hi-C and RNA-seq followed by data analysis and validations of key results in wet lab studies including CRISPR-Cas9 editing.

The immediate research environment is the translational acute leukemia research group of Sören Lehmann. The group works with basic as well as translational and clinical research, especially focused on acute myeloid leukemia. This is an inspiring and interdisciplinary work environment which includes basic scientists as well as clinical doctors and biostatisticians. The Lehmann group works in close collaborations with other excellent research groups at Uppsala University, Karolinska Institute and within international networks. The project has academic as well as commercial collaborators. 

Requirements
The position requires a PhD or a foreign degree equivalent to a PhD. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc. The passed PhD should be within a relevant research subject such as genetics, epigenetics, cancer and/or hematology related molecular biology. Desired skills include experience in basic laboratory techniques for analysis of DNA, RNA and protein and experience from bioinformatic handling of data. An emphasis will be given to scientific excellence within the field as well as organization and cooperation skills.

Additional qualifications
Experience in epigenetic techniques and/or and statistics is a strength.

About the employment
The employment is a temporary position of at least 2 years and at most 3 years. Scope of employment is 100%. Starting date as agreed.

For further information about the position, please contact: Professor Sören Lehmann, Soren.Lehmann@medsci.uu.se

Please submit your application by 2nd February 2023, UFV-PA 2022/5090.

Please do not send offers of recruitment or advertising services.

Submit your application through Uppsala University's recruitment system.

Placement: Department of Medical Sciences

Type of employment: Full time , Temporary position longer than 6 months

Pay: Fast lön

Number of positions: 1

Working hours: 100

Town: uppsala

County: Uppsala län

Country: Sweden

Union representative: Seko Universitetsklubben seko@uadm.uu.se
ST/TCO tco@fackorg.uu.se
Saco-rådet saco@uadm.uu.se

Number of reference: UFV-PA 2022/5090

Last application date: 2023-02-02