Postdoctoral Fellow in Multi-scale Computational Studies of Enzymes involved in Biological Energy Conversion (2)

Updated: about 1 month ago

at the Department of biochemistry and biophysics . Closing date: 28 June 2021

The Department of Biochemistry and Biophysics at Stockholm University is a world-leading research institute within biochemical basic research. It is one of the largest departments at the Faculty of Science with about 300 employees (including around 110 PhD students) across more than 30 active research groups that span across a broad range of topics covering various aspects of structure and function of biological systems. The combination of the highly interdisciplinary expertise and research projects at the Departments is unique in Sweden and internationally. This expertise ranges across different topics of biochemistry, cell biology, and biophysics with a main focus on biological membranes. Specific research topics include: membrane protein structure, function, and disease; protein folding and trafficking; biological energy conversion; bioinformatics; computational structural biology, biochemistry, and development of various computational tools.

Project description
The Kaila Lab at Stockholm University seeks outstanding candidates to work on structure-function relationships of membrane-bound bioenergetic enzymes with a focus on the proton-coupled electron transfer (PCET) mechanism in Complex I and related proteins. The project is carried out by multi-scale methods of computational biochemistry/biophysics with aims to understand principles of biological energy catalysis at a molecular level. The project is supported by the European Research Council (ERC) and the Knut and Alice Wallenberg Foundation (KAW).

Project related publications: Röpke et al. JACS 2020, Brigdes et al. Nature Comms 2020; Mühlbauer et al. JACS 2020; Schuller et al. Nature Comms 2020; Jussupow et al. Science Adv. 2019; Saura et al. JACS 2019; Warnau et al. PNAS 2019; Kaila J Roy Soc Interfaces 2018; Di Luca et al. PNAS 2017; Gamiz-Hernandez et al. JACS 2017.

Main responsibilities
The candidate will study the structure, function, and dynamics of studies proteins involved in biological energy conversion, with a main emphasis on respiratory Complex I and biological PCET reactions.  

Qualification requirements
Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country.

Assessment criteria
The degree should have been completed no more than three years before the deadline for applications. An older degree may be acceptable under special circumstances, which may involve sick leave, parental leave, clinical attachment, elected positions in trade unions, or similar.

The candidate should have prior experience in computational multi-scale methods applied to biological systems. In the appointment process, special attention will be given to scientific excellence and personal competence, as well as researchers working with enzyme mechanisms and membrane protein function. The candidate should be able to work independently, but the project has also many collaborative aspects, and prior experience in collaborative projects is therefore desired. The candidate is experienced in the application and/or development of quantum chemical or hybrid QM/MM methods, atomistic MD simulations, coarse-grained simulations, and/or free energy calculations. Great emphasis will be placed on personal competency.

Terms of employment
The position involves full-time employment for a maximum of two years, with the possibility of extension under special circumstances. Start date as per agreement.

Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Further information about the position can be obtained from Professor Ville Kaila, telephone: +46 8 16 42 40, .

Union representatives
Ingrid Lander (Saco-S), telephone: +46 708 16 26 64, , Alejandra Pizarro Carrasco (Fackförbundet ST/Lärarförbundet), telephone: +46 8 16 34 89, , and (SEKO).

Apply for the position at Stockholm University's recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

Please include the following information with your application

  • Your contact details and personal data
  • Your highest degree
  • Your language skills
  • Contact details for 2–3 references

and, in addition, please include the following documents

  • Cover letter
  • CV – degrees and other completed courses, work experience and a list of publications
  • Research proposal (no more than 3 pages) describing:
    – why you are interested in the field/project described in the advertisement
    – why and how you wish to complete the project
    – what makes you suitable for the project in question
  • Copy of PhD diploma
  • Letters of recommendation (no more than 3 files)
  • Publications in support of your application (no more than 3 files).

The instructions for applicants are available at: How to apply for a position .

You are welcome to apply!

Stockholms universitet bidrar till det hållbara demokratiska samhällets utveckling genom kunskap, upplysning och sanningssökande.

Closing date: 28/06/2021

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