Postdoctoral fellow in Cryo EM of mitochondrial DNA transcription and

The University of Gothenburg tackles society’s challenges with diverse knowledge. 53 500 students and 6 500 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.

The Institute is composed of the following four departments:

• The Department of Infectious Diseases
• The Department of Microbiology and Immunology
• The Department of Medical Biochemistry and Cell Biology
• The Department of Laboratory Medicine

At present, the institute has about 360 employees and approximately 450 million SEK in total assets

Cryo EM of mitochondrial DNA transcription and replication

Mitochondria contain their own genome that codes for several subunits of the respiratory chain. We have developed in vivo and in vitro techniques to study the basic mechanisms of human mitochondrial DNA transcription and replication, and how these processes are regulated.

With this project the candidate will study the structure of the mitochondrial replisome using cryo EM. The aim of this project is to study the molecular mechanisms of DNA replication and/or transcription, with special emphasis on the structure and how different disease forming mutations affect the structure formation. The project mainly involves work with purified proteins and cryo EM experiments.

An achieved doctoral degree is compulsory for a position as post doctor at the University of Gothenburg. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as post doctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.

The qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.

We are looking for a highly motivated individual with significant experience in cryo EM and/or structural biology. Knowledge of mitochondrial systems and documented experience with cloning, mutagenesis, gene expression, cell culture, radiolabeled isotopes, and in vitro DNA replication and/or transcription are of merit. The work will involve collaboration both within and outside the group, and so good teamwork and communication skills are important. The candidate is expected to be enthusiastic, capable of planning and executing research independently, and to have a passion and curiosity for science. Fluent written and spoken English is required since we operate in a very international environment.

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.

The employment is full time and temporary, two years, with placement at the Institute of Biomedicine. First day of employment as agreed.

Please contact: Maria Falkenberg, Professor, +46 (0)317863444, [email protected]

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In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

The application should contain:

- A cover letter giving a brief description of previous research experience, and a motivation to why you are applying

- A detailed CV including a list of publications

- Proof of completed PhD

- Contact details of two references.

Closing date: 2022-01-16

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.