Postdoctor in Molecular

University of Gothenburg, Sweden

Updated: over 1 year ago
Deadline: Fixed term

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Department of Molecular and Clinical Medicine, at the Institute of Medicine, conducts translational research primarily on metabolism, diabetes, obesity and cardiovascular disease in order to improve health and healthcare in the community. The overall goal is to create an excellent translational research environment of a very high international standard.

The post-doc will perform research in the group of Prof. Giovanni Solinas. Research in the lab focuses on the role of different class-1 PI3K in the insulin system in the context of obesity, diabetes, and cancer.


Subject area 

Molecular Medicine


Subject area description 

Research in our group is focused on the study of the role of PI3K signaling at the interface between metabolic homeostasis and tissue homeostasis, with direct implication to the therapy of Obesity, Diabetes, and Cancer. More specifically, research will focus on the role of PI3K isoforms in the development of diet-induced obesity and insulin resistance using genetically modified mice, pharmacological inhibitors, viral vectors and primary cell culture (mouse and human).

Selected readings:

  • PI3Kγ Promotes Obesity-associated Hepatocellular Carcinoma by Regulating Metabolism and Inflammation. JHEP Reports 2021 December 2021,100359 https://doi.org/10.1016/j.jhepr.2021.100359
  • Obese Insulin Resistant Humans Dissociate Free Fatty Acids and Glycerol Homeostasis from Glycaemia as Possible Adaptive Response to Fatness. EBioMedicine 2021 PMID: 33712379
  • Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS. Cell Metabolism 2019 PMID:30982732
  • PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis. FASEB J. 2018 PMID: 28904022
  • PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Science Signaling 2017 PMID:28720716

    • Duties 

    100% Research. Pre-clinical studies (mice/rats and primary cell culture, human and rodents), data analysis and organization, group presentations as well as participation to external conferences. The postdoctoral project focuses on defining the role of PI3K isoforms in the development of obesity and insulin resistance using genetically modified mice, pharmacological inhibitors, viral vectors and primary cell culture (mouse and human).


    Eligibility

    To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject. Since postdoctoral constitutes a qualifying appointment for junior researchers, we aim to target those who have a doctoral degree not older than 3 years.


    Assessment criteria 

    Selection will be based on CV and interview of candidates by videoconference. Specific requirements: PhD degree in a life sciences/biomedicine related field. Previous experience in one or more of these disciplines is desired: physiology; cell biology; signal transduction; molecular biology; biochemistry; metabolism; cancer.

    It is required that the applicant is fluent in English both written and spoken, has a collaborative approach, and is passionate about experimental science and hands-on lab work.

    Great emphasis will be placed on personal suitability.


    Employment 

    Type of employment: Fixed-term employment, 24 months Extent: 100 % Location: Institute of Medicine, Gothenburg First day of employment: According to agreement, not later than March 31st 2023.   


    Contact information 

    Giovanni Solinas, Professor, [email protected]

    Malin Levin, Head of department, [email protected]


    Unions 

    Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande  


    Information for International Applicants

    Visit the webpage Join us - jobs and career  for more information on the Institute of Medicine and what opportunities we have for you. Discover our world-class research and research infrastructure, as well as what the benefits are for you and your family.


    Application 

    Please attach PhD certificate with the application, if the PhD certificate has not yet been issued, it needs to be attached latest at the time when the employment decision is to be made.

    Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

    Applications must be received by: 2022-12-19

    The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

    Salaries are set individually at the University.

    In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

    In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.


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