One postdoc on scholarship in Systems Biology of human disease

The workplace

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

SciLifeLab is a national resource center dedicated to large scale bioscientific research with focus on biomedicine, including genome and proteome profiling, bioimaging and bioinformatics. SciLifeLab Stockholm has been formed jointly by the three Stockholm universities, Royal Institute of Technology (KTH), Karolinska Institutet (KI) and Stockholm University (SU), and thus combines the profiles and strengths of these three institutions. Academic research as well as the Swedish health care system and the Swedish Life Science industry will benefit through active collaboration, access to advanced tools and active programs for knowledge transfer. The goal is to achieve critical mass for large-scale life sciences and translational medicine.

https://www.kth.se/en/cbh/skolan-for-kemi-bioteknologi-och-halsa-1.763561

">https://www.kth.se/en/cbh/skolan-for-kemi-bioteknologi-och-halsa-1.76356...

Project description

Mardinoglu lab at SciLifeLab develop genome-scale metabolic models (GEMs) for human cells/tissues and employ these comprehensive models in the analysis of the omics data obtained from subjects with complex diseases including non-alcoholic fatty liver disease, type 2 diabetes and certain types of cancer (e.g. hepatocellular carcinoma). This is an exciting area of biomedical research, driven by the recent discoveries of metabolic reprogramming in common complex diseases.

The candidate are expected to perform research in Systems Biology, Systems Medicine, Network Medicine and Bioinformatics

The candidate will integrate the liver GEMs with other biological networks including regulatory, protein-protein interactions (PPIs) and co-expression networks. The candidate will use these biological networks in the analysis of the omics data obtained from different clinical conditions to identify drug targets and discover biomarker for the development of the efficient diagnostic and treatment strategies for liver diseases including non-alcoholic steatohepatitis and hepatocellular carcinoma.

The candidate will also use systems biology tools to perform identify potential drugs for treatment of the disease which will be later validated in the lab.

The candidate will be working closely with the experimental groups as well as clinicians. More information can be found at ">http://sysmedicine.com

Qualifications

• A doctoral degree or an equivalent foreign degree, obtained within the last three years prior to the application deadline.
• Educational background within bioinformatics, systems biology and/ or mathematics.     
• Experience from analysis of the next-generation sequencing data.
• Experience from programming numerical algorithms in languages such as MatLab, R and Python.
• Highly motivated for doing scientific research related to human diseases.
• Excellent written and oral communication skills.
• Good knowledge of English in speech and writing is necessary to publish and present research results in international conferences and journals.
• Awareness of diversity and equal treatment issues with a particular focus on gender equality.

Preferred qualifications

• Strong publication record.
• Experience of network models/graph theory.

Personal qualifications

• Educational ability
• Teamwork
• Well-developed analytical and problem solving skills.
• Independence

 Great emphasis will be placed on personal competence and suitability.

Application                                 

Apply to this scholarship by e-mail HR representative Sandra Nylén [email protected]

You are the main responsible to ensure that your application is complete according to the ad. Your complete application must be received at KTH no later than 2022-02-17. Mark the e-mail subject line and application with reference number C-2022-0144.

The application must include the following documents:

• Curriculum vitae
• Cover letter (detailing both your previous scientific work experience and your interest in this position)
• Contact information for three references

Please observe that you apply for a scholarship, not an employment

About the position/positions

Period: From March 2022 (flexible start). 1+1 (1 year with possibility to be prolonged another year.

Extent: Full-time

Number of positions: 1

Amount of scholarship: 27 000 SEK/month, (payment according KTH policy for scholarship)

Location: Science for Life Laboratory, Stockholm

Contact

Doctor Cheng Zhang, e-mail: cheng.zhang">mailto:[email protected]">cheng.zhang @scilifelab.se

Associated Professor Adil Mardinoglu, e-mail: [email protected]

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