Ref PAR 2024/135
The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
Doctoral position in Medical Science
Project title: Genetic variants in clonal hematopoiesis and blood cancer
One additional doctoral student position is currently announced. For more information, see the announcement PAR 2024/134.
The Department of Medical Biochemistry and Cell biology, is located at the Institute of Biomedicine at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg.
Duties
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Clonal hematopoiesis (CH) is an early stage of blood cancer development, where a large fraction of blood cells originates from a single hematopoietic stem cell lineage. CH can be detected in DNA sequencing data from blood cells of healthy individuals based on somatic genetic variants. CH with somatic variants in blood cells of healthy individuals carries an increased risk of leukemia and age-related diseases. Recently, we distinguished clonal hematopoiesis into myeloid and lymphoid sub-groups and stratified risk of developing distinct types of blood cancers (Niroula et al., Nature Medicine 2021).
In this PhD project, we aim to identify new genetic variations that initiate CH and lead to blood malignancies. As a PhD student, you will use advanced bioinformatics and statistical methods to analyze large-scale next-generation sequencing (NGS) data and multi-omics data. The project involves extensive use of high-performance computing (HPC) platforms. The PhD student will work in a data-driven life science (DDLS) research team affiliated to the Wallenberg Centre for Molecular and Translational Medicine (WCMTM, https://www.gu.se/en/molecular-translational-medicine ) and the SciLifeLab and Wallenberg National Program for DDLS (https://www.scilifelab.se/data-driven/ ).
The applicant should be able to work independently and in collaborative teams. Previous experience in programming (R or python), UNIX operating system, and research in human genomics is desirable.
Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.
Eligibility
Education at third-cycle level requires general eligibility and specific eligibility as set out in the general syllabus for the subject.
The general eligibility requirements for education at third-cycle level are:
1. having completed a degree at second-cycle level, or
2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or
3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad.
Specific entry requirements for this subject, according to the general syllabus, are:
having completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
Assessment criteria
The selection of applicants who are considered to have the ability required to benefit from the study programme and who meet the general and specific eligibility requirements are assessed based on the following documented qualifications: – specific knowledge and skills within the subject area and related research fields
– experience of scientific theory and relevant research methodology
– scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
Employment
Once you have been admitted for education at third-cycle level, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at third-cycle level for four years.
Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Medical Biochemistry and Cell biology. Extent: 100%. First day of employment: as agreed.
The University applies a local agreement on salaries for doctoral students.
Similar Positions
-
Doctoral Student In Medical Science Nox2 Derived Ros In The Tumor Milieu, University of Gothenburg, Sweden, 27 days ago
3 Apr 2024 Job Information Organisation/Company University of Gothenburg Research Field Medical sciences » Medicine Researcher Profile First Stage Researcher (R1) Country Sweden Application Deadli...
-
Ph.D. Student In Medical Radiation Physics With A Focus On Mr Physics, Lunds universitet, Sweden, about 20 hours ago
27 Apr 2024 Job Information Organisation/Company Lunds universitet Department Lunds universitet, avd för medicinsk strålningsfysik Research Field Medical sciences » Medicine Researcher Profile Fir...
-
Ph.D. Student In Medical Radiation Physics With A Focus On Mr Physics (Pa2024/1315) , University of Lund, Sweden, about 21 hours ago
The Department of Medical Radiation Physics is engaged in research and education in ionizing and non-ionizing radiation, and its use mainly in medical applications. The major areas are magnetic re...
-
Doctoral Student With Focus On Combustion Modelling In Battery Systems During Thermal Runaway (Pa2024/1101) , University of Lund, Sweden, about 22 hours ago
Description of the workplace The position is located at the Division of Heat Transfer at the Department of Energy Sciences. At the division, we conduct research and education on the energy generat...
-
Doctoral Student In Biology (Pa2024/1401) , University of Lund, Sweden, about 21 hours ago
Biology is the broad subject about all living things. It encompasses everything from processes at the molecular and cellular level to global processes at ecosystem level. The subject is divided in...
-
Doctoral Student In Medical Science Tumor Microvascular Characterization With Mri, University of Gothenburg, Sweden, 11 days ago
18 Apr 2024 Job Information Organisation/Company University of Gothenburg Research Field Medical sciences » Medicine Researcher Profile First Stage Researcher (R1) Country Sweden Application Deadl...