Doctoral (PhD) student position in Genome integrity (KID)

Updated: 7 months ago
Deadline: The position may have been removed or expired!

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board.

For more information regarding doctoral (PhD) education, see: . 

Research group
The lab of Lena Ströms research group is residing in the scientifically stimulating atmosphere of the department of Cell and Molecular biology at Solna campus, KI. We are working in close connection to neighboring groups studying similar topics, and the groups of the co-supervisors of the intended student. The general interest of the research group is Genome Integrity through the SMC protein family, especially Cohesin and its chromatin loader Scc2/4 using both budding yeast and human cell lines as model systems.

The doctoral education project and the duties of the student
The aims of this PhD project will be to study the overall regulation and molecular mechanism of the Scc2/4 complex and its vertebrate counterpart NIPBL/MAU2, with the specific goals to:

Determine cell cycle specific and DNA damage dependent posttranslational modifications of Scc2/4 and their importance for the regulation of the complex, and to functionally analyze NIPBL mutations in a newly developed human cell expression system

The project involves both in vitro and in vivo experiments using various model systems including yeast and human cell lines. After suitable supervision the student is supposed to be able to work on all parts of the project including design and execution of experiments.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  • has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  • has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  • has acquired substantially equivalent knowledge in some other way in Sweden or abroad.
  • Specific entry requirements
    Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
    Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
    Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

    For more information regarding general and specific entry requirements:

    Skills and personal qualities
    The successful candidate needs to be strongly motivated and able to work independently and at the same time content with working in teams. Experience from work with cell culture, molecular biology and biochemistry methods as well as microscopy techniques are required. In addition experience from Mass spectrometry will be beneficial. The PhD candidate is expected to be able to work carefully and ambitiously. The working language is english.

    Assessment criteria
    A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
    - Documented subject knowledge of relevance to the area of research
    - Analytical skill
    - Other documented knowledge or experience that may be relevant to doctoral studies in the subject

    The qualifications of the applicants will be evaluated on an overall basis.

    Terms and conditions
    All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

    Application process
    An application must contain the following documents in Swedish or English:

    • A personal letter and curriculum vitae
    • A copy of degree certificates and associated certificates
    • A copy of degree projects and any previous publications

    The application is to be submitted through the MyNetwork recruitment system.

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